[HTML][HTML] Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis

Y Feng, M Spezia, S Huang, C Yuan, Z Zeng, L Zhang… - Genes & diseases, 2018 - Elsevier
As the most commonly occurring cancer in women worldwide, breast cancer poses a
formidable public health challenge on a global scale. Breast cancer consists of a group of …

[HTML][HTML] Phenotypic plasticity: driver of cancer initiation, progression, and therapy resistance

PB Gupta, I Pastushenko, A Skibinski, C Blanpain… - Cell stem cell, 2019 - cell.com
Our traditional understanding of phenotypic plasticity in adult somatic cells comprises
dedifferentiation and transdifferentiation in the context of tissue regeneration or wound …

Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy

PR Dandawate, D Subramaniam, RA Jensen… - Seminars in cancer …, 2016 - Elsevier
Breast cancer is the most common form of cancer diagnosed in women worldwide and the
second leading cause of cancer-related deaths in the USA. Despite the development of …

Ciliary signalling in cancer

H Liu, AA Kiseleva, EA Golemis - Nature Reviews Cancer, 2018 - nature.com
Although tumours initiate from oncogenic changes in a cancer cell, subsequent tumour
progression and therapeutic response depend on interactions between the cancer cells and …

Role of hedgehog signaling in breast cancer: pathogenesis and therapeutics

NA Riobo-Del Galdo, A Lara Montero, EV Wertheimer - Cells, 2019 - mdpi.com
Breast cancer (BC) is the leading cause of cancer-related mortality in women, only followed
by lung cancer. Given the importance of BC in public health, it is essential to identify …

Functional aspects of primary cilia in signaling, cell cycle and tumorigenesis

SG Basten, RH Giles - Cilia, 2013 - Springer
Dysfunctional cilia underlie a broad range of cellular and tissue phenotypes and can
eventually result in the development of ciliopathies: pathologically diverse diseases that …

EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling

VJ Guen, TE Chavarria, C Kröger… - Proceedings of the …, 2017 - National Acad Sciences
Tissue regeneration relies on adult stem cells (SCs) that possess the ability to self-renew
and produce differentiating progeny. In an analogous manner, the development of certain …

Targeting breast cancer stem cells through retinoids: a new hope for treatment

N Jan, S Sofi, H Qayoom, BU Haq, A Shabir… - Critical Reviews in …, 2023 - Elsevier
Breast cancer is a complex and diverse disease accounting for nearly 30% of all cancers
diagnosed in females. But unfortunately, patients develop resistance to the existing …

The hedgehog pathway in triple‐negative breast cancer

JG Habib, JA O'Shaughnessy - Cancer medicine, 2016 - Wiley Online Library
Abstract Treatment of triple‐negative breast cancer (TNBC) remains challenging due to the
underlying heterogeneity of this disease coupled with the lack of predictive biomarkers and …

The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy

M Hui, A Cazet, R Nair, DN Watkins, SA O'Toole… - Breast Cancer …, 2013 - Springer
Despite the progress achieved in breast cancer screening and therapeutic innovations, the
basal-like subtype of breast cancer (BLBC) still represents a particular clinical challenge. In …