Lipids and lipid derivatives for RNA delivery

Y Zhang, C Sun, C Wang, KE Jankovic… - Chemical reviews, 2021 - ACS Publications
RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …

Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications

SM Dadfar, K Roemhild, NI Drude… - Advanced drug delivery …, 2019 - Elsevier
Many different iron oxide nanoparticles have been evaluated over the years, for a wide
variety of biomedical applications. We here summarize the synthesis, surface …

Magnetic nanoparticles in cancer therapy and diagnosis

A Farzin, SA Etesami, J Quint, A Memic… - Advanced healthcare …, 2020 - Wiley Online Library
There is urgency for the development of nanomaterials that can meet emerging biomedical
needs. Magnetic nanoparticles (MNPs) offer high magnetic moments and surface‐area‐to …

Advances in magnetic nanoparticles for biomedical applications

VF Cardoso, A Francesko, C Ribeiro… - Advanced …, 2018 - Wiley Online Library
Magnetic nanoparticles (NPs) are emerging as an important class of biomedical functional
nanomaterials in areas such as hyperthermia, drug release, tissue engineering, theranostic …

Targeted drug delivery with polymers and magnetic nanoparticles: covalent and noncovalent approaches, release control, and clinical studies

K Ulbrich, K Hola, V Subr, A Bakandritsos… - Chemical …, 2016 - ACS Publications
Targeted delivery combined with controlled drug release has a pivotal role in the future of
personalized medicine. This review covers the principles, advantages, and drawbacks of …

Iron oxide based nanoparticles for multimodal imaging and magnetoresponsive therapy

N Lee, D Yoo, D Ling, MH Cho, T Hyeon… - Chemical …, 2015 - ACS Publications
Magnetic nanoparticles have received tremendous attention in diverse fields because of
their unique nanoscale physicochemical properties and the potential for a wide range of …

Rekindling RNAi therapy: materials design requirements for in vivo siRNA delivery

B Kim, JH Park, MJ Sailor - Advanced materials, 2019 - Wiley Online Library
With the recent FDA approval of the first siRNA‐derived therapeutic, RNA interference
(RNAi)‐mediated gene therapy is undergoing a transition from research to the clinical …

Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery

VP Torchilin - Nature reviews Drug discovery, 2014 - nature.com
The use of nanoparticulate pharmaceutical drug delivery systems (NDDSs) to enhance the
in vivo effectiveness of drugs is now well established. The development of multifunctional …

Nonviral cancer gene therapy: delivery cascade and vector nanoproperty integration

Z Zhou, X Liu, D Zhu, Y Wang, Z Zhang, X Zhou… - Advanced drug delivery …, 2017 - Elsevier
Gene therapy represents a promising cancer treatment featuring high efficacy and limited
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …

Chemistry, biology, and medicine of fluorescent nanomaterials and related systems: new insights into biosensing, bioimaging, genomics, diagnostics, and therapy

J Yao, M Yang, Y Duan - Chemical reviews, 2014 - ACS Publications
2. INTRODUCTION The investigation of many fundamental processes in life sciences
requires straightforward tools for fast, sensitive, reliable, and reproducible detection of …