Behçet's disease is a systemic vasculitis frequently associated with intraocular inflammation.
Recent findings identified independent clinical clusters in Behçet's disease, each involving …

Uveitis is a group of diseases characterized by intraocular inflammation, of which some are
driven by autoinflammatory or autoimmune responses, such as Vogt-Koyanagi-Harada …

Background Behcet's disease (BD) is a recalcitrant, multisystemic inflammatory disease that
can lead to irreversible blindness. Microbial agents have been considered to contribute to …

Oxidative stress is a major contributor to the pathogenesis of various inflammatory diseases.
Accumulating evidence has shown that oxidative stress is characterized by the …

With the rapid development of metagenomic high-throughput sequencing technology, more
and more oral mucosal diseases have been proven to be associated with oral microbiota …

Background Macrophages are key innate immune cells implicated in the pathogenesis of
Behçet's disease (BD), and macrophage polarization plays a pivotal role in inflammatory …

Inflammasomes, key molecular regulators that play an important role in inflammation, consist
of a central protein, an adaptor protein ASC (apoptosis speck-like protein) and a caspase-1 …

Abstract We analyzed 1,900 Turkish Behçet's disease cases and 1,779 controls genotyped
with the Immunochip. The most significantly associated SNP was rs1050502, a tag SNP for …

Mitochondrial DNA (mtDNA) leakage into the cytoplasm can occur when cells are exposed
to noxious stimuli. Specific sensors recognize cytoplasmic mtDNA to promote cytokine …

IL‐1β is one of the main proinflammatory cytokines that regulates a broad range of immune
responses and also participates in several physiological processes. The canonical …