The sodium and potassium gradients across the plasma membrane are used by animal cells
for numerous processes, and the range of demands requires that the responsible ion pump …

Parkinson's disease (PD) is a neurodegenerative disorder that affects about 1.5% of the
global population over 65 years of age. A hallmark feature of PD is the degeneration of the …

The striatum contributes to many cognitive processes and disorders, but its cell types are
incompletely characterized. We show that microfluidic and FACS-based single-cell RNA …

Decades of experimental work have established an imbalance of excitation and inhibition as
the leading mechanism of the transition from normal brain function to seizure. In epilepsy …

The CLDN5 gene encodes claudin-5 (CLDN-5) that is expressed in endothelial cells and
forms tight junctions which limit the passive diffusions of ions and solutes. The blood–brain …

Dystonia is a neurological condition characterized by abnormal involuntary movements or
postures owing to sustained or intermittent muscle contractions. Dystonia can be the …

Dopamine‐releasing neurons within the Substantia nigra (SN DA) are particularly
vulnerable to degeneration compared to other dopaminergic neurons. The age‐dependent …

Epilepsy genes deliver critical insights into the molecular control of brain synchronization
and are revolutionizing our understanding and treatment of the disease. The epilepsy …

During neuronal activity in the brain, extracellular K+ rises and is subsequently removed to
prevent a widespread depolarization. One of the key players in regulating extracellular K+ is …

Neurodegeneration correlates with Alzheimer's disease (AD) symptoms, but the molecular
identities of pathogenic amyloid β-protein (Aβ) oligomers and their targets, leading to …