Barriers for HIV cure: the latent reservoir
S Castro-Gonzalez, M Colomer-Lluch… - AIDS research and …, 2018 - liebertpub.com
Thirty-five years after the identification of HIV-1 as the causative agent of AIDS, we are still in
search of vaccines and treatments to eradicate this devastating infectious disease. Progress …
search of vaccines and treatments to eradicate this devastating infectious disease. Progress …
HIV-1 eradication: early trials (and tribulations)
AM Spivak, V Planelles - Trends in molecular medicine, 2016 - cell.com
Antiretroviral therapy (ART) has rendered HIV-1 infection a manageable illness for those
with access to treatment. However, ART does not lead to viral eradication owing to the …
with access to treatment. However, ART does not lead to viral eradication owing to the …
The landscape of persistent viral genomes in ART-treated SIV, SHIV, and HIV-2 infections
Evaluation of HIV cure strategies is complicated by defective proviruses that persist in ART-
treated patients but are irrelevant to cure. Non-human primates (NHP) are essential for …
treated patients but are irrelevant to cure. Non-human primates (NHP) are essential for …
A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy
Background Despite improved clinical outcomes seen following antiretroviral therapy (ART),
resting CD4+ T cells continue to harbor latent human immunodeficiency virus type one (HIV …
resting CD4+ T cells continue to harbor latent human immunodeficiency virus type one (HIV …
Animal models for HIV cure research
BB Policicchio, I Pandrea, C Apetrei - Frontiers in immunology, 2016 - frontiersin.org
The HIV-1/AIDS pandemic continues to spread unabated worldwide, and no vaccine exists
within our grasp. Effective antiretroviral therapy (ART) has been developed, but ART cannot …
within our grasp. Effective antiretroviral therapy (ART) has been developed, but ART cannot …
CCR5Δ32 mutation and HIV infection: basis for curative HIV therapy
K Allers, T Schneider - Current opinion in virology, 2015 - Elsevier
Highlights•Homozygous CCR5Δ32/Δ32 mutation renders cells deficient of CCR5 surface
expression.•Naturally CCR5-deficient immune cells are resistant to infection with CCR5 …
expression.•Naturally CCR5-deficient immune cells are resistant to infection with CCR5 …
Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques
AM Cadena, JD Ventura, P Abbink… - Nature …, 2021 - nature.com
The establishment of a long-lived viral reservoir is the key obstacle for achieving an HIV-1
cure. However, the anatomic, virologic, and immunologic features of the viral reservoir in …
cure. However, the anatomic, virologic, and immunologic features of the viral reservoir in …
Genome editing in large animal models
Although genome editing technologies have the potential to revolutionize the way we treat
human diseases, barriers to successful clinical implementation remain. Increasingly …
human diseases, barriers to successful clinical implementation remain. Increasingly …
Maintenance of the HIV reservoir is antagonized by selective BCL2 inhibition
NW Cummins, AM Sainski-Nguyen… - Journal of …, 2017 - Am Soc Microbiol
Decay of the HIV reservoir is slowed over time in part by expansion of the pool of HIV-
infected cells. This expansion reflects homeostatic proliferation of infected cells by …
infected cells. This expansion reflects homeostatic proliferation of infected cells by …
Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral …
NW Cummins, S Rizza, MR Litzow, S Hua… - PLoS …, 2017 - journals.plos.org
Background Notwithstanding 1 documented case of HIV-1 cure following allogeneic stem
cell transplantation (allo-SCT), several subsequent cases of allo-SCT in HIV-1 positive …
cell transplantation (allo-SCT), several subsequent cases of allo-SCT in HIV-1 positive …