It is widely reported that the mitochondrial membrane potential,∆ Ψm, is reduced in aging
animals. It was recently suggested that the lower∆ Ψm in aged animals modulates …

The intestinal barrier, composed of the luminal microbiota, the mucus layer, and the physical
barrier consisting of epithelial cells and immune cells, the latter residing underneath and …

Cellular senescence and the senescence-associated secretory phenotype (SASP) are
implicated in aging and age-related disease, and SASP-related inflammation is thought to …

Summary EGFR-RAS-ERK signaling promotes growth and proliferation in many cell types,
and genetic hyperactivation of RAS-ERK signaling drives many cancers. Yet, despite …

In adult insects, as in vertebrates, the gut epithelium is a highly regenerative tissue that can
renew itself rapidly in response to changing inputs from nutrition, the gut microbiota …

Stem cells have essential functions in the development and maintenance of our organs.
Improper regulation of adult stem cells and tissue homeostasis can result in cancers and …

Tissue regeneration after injury requires coordinated regulation of stem cell activation,
division, and daughter cell differentiation, processes that are increasingly well understood in …

Long dismissed as merely harmful respiratory by-products, Reactive Oxygen Species (ROS)
have emerged as critical intracellular messengers during cell growth and differentiation …

Reprogramming energy production from mitochondrial respiration to glycolysis is now
considered a hallmark of cancer. When tumors grow beyond a certain size they give rise to …

Metabolic switches are a crucial hallmark of cellular development and regeneration. In
response to changes in their environment or physiological state, cells undergo coordinated …