Given the functional interdependencies between the molecular components in a human cell,
a disease is rarely a consequence of an abnormality in a single gene, but reflects the …

Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Brain networks or 'connectomes' include a minority of highly connected hub nodes that are
functionally valuable, because their topological centrality supports integrative processing …

Coexpression networks and gene regulatory networks (GRNs) are emerging as important
tools for predicting functional roles of individual genes at a system-wide scale. To enable …

Complex biological systems and cellular networks may underlie most genotype to
phenotype relationships. Here, we review basic concepts in network biology, discussing …

Eight members of the Herpesviridae family commonly infect humans, and close to 100% of
the adult population is infected with at least one of these. The five that cause the most health …

Plants generate effective responses to infection by recognizing both conserved and variable
pathogen-encoded molecules. Pathogens deploy virulence effector proteins into host cells …

Human immunodeficiency virus (HIV) has a small genome and therefore relies heavily on
the host cellular machinery to replicate. Identifying which host proteins and complexes come …

Influenza A viruses are a major cause of mortality. Given the potential for future lethal
pandemics, effective drugs are needed for the treatment of severe influenza such as that …

During a decade of proof-of-principle analysis in model organisms, protein networks have
been used to further the study of molecular evolution, to gain insight into the robustness of …