Hallmarks of brain aging: adaptive and pathological modification by metabolic states

MP Mattson, TV Arumugam - Cell metabolism, 2018 - cell.com
During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …

Executive function in autism spectrum disorder: history, theoretical models, empirical findings, and potential as an endophenotype

EA Demetriou, MM DeMayo, AJ Guastella - Frontiers in psychiatry, 2019 - frontiersin.org
This review presents an outline of executive function (EF) and its application to autism
spectrum disorder (ASD). The development of the EF construct, theoretical models of EF …

Preprocessing, analysis and quantification in single‐voxel magnetic resonance spectroscopy: experts' consensus recommendations

J Near, AD Harris, C Juchem, R Kreis… - NMR in …, 2021 - Wiley Online Library
Once an MRS dataset has been acquired, several important steps must be taken to obtain
the desired metabolite concentration measures. First, the data must be preprocessed to …

[HTML][HTML] GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer's disease

J Jiménez-Balado, TS Eich - Seminars in cell & developmental biology, 2021 - Elsevier
In this review, we focus on the potential role of the γ-aminobutyric acidergic (GABAergic)
system in age-related episodic memory impairments in humans, with a particular focus on …

Intracortical GABAergic dysfunction in patients with fatigue and dysexecutive syndrome after COVID-19

V Versace, L Sebastianelli, D Ferrazzoli… - Clinical …, 2021 - Elsevier
Objective A high proportion of patients experience fatigue and impairment of cognitive
functions after coronavirus disease 2019 (COVID-19). Here we applied transcranial …

Altered motor cortex physiology and dysexecutive syndrome in patients with fatigue and cognitive difficulties after mild COVID‐19

P Ortelli, D Ferrazzoli, L Sebastianelli… - European journal of …, 2022 - Wiley Online Library
Background and purpose Fatigue and cognitive difficulties are reported as the most
frequently persistent symptoms in patients after mild SARS‐CoV‐2 infection. An extensive …

Changes in EEG multiscale entropy and power‐law frequency scaling during the human sleep cycle

V Miskovic, KJ MacDonald, LJ Rhodes… - Human brain …, 2019 - Wiley Online Library
We explored changes in multiscale brain signal complexity and power‐law scaling
exponents of electroencephalogram (EEG) frequency spectra across several distinct global …

The trajectory of cortical GABA across the lifespan, an individual participant data meta-analysis of edited MRS studies

EC Porges, G Jensen, B Foster, RAE Edden, NAJ Puts - Elife, 2021 - elifesciences.org
γ-Aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the human brain
and can be measured with magnetic resonance spectroscopy (MRS). Conflicting accounts …

Sensorimotor network segregation declines with age and is linked to GABA and to sensorimotor performance

K Cassady, H Gagnon, P Lalwani, M Simmonite… - Neuroimage, 2019 - Elsevier
Aging is typically associated with declines in sensorimotor performance. Previous studies
have linked some age-related behavioral declines to reductions in network segregation. For …

A ketogenic diet improves cognition and has biochemical effects in prefrontal cortex that are dissociable from hippocampus

AR Hernandez, CM Hernandez, K Campos… - Frontiers in aging …, 2018 - frontiersin.org
Age-related cognitive decline has been linked to a diverse set of neurobiological
mechanisms, including bidirectional changes in proteins critical for neuron function …