The continuous demand of medicinally important scaffolds has prompted the synthetic
chemists to identify simple and efficient routes for their synthesis. 1H-1, 2, 3-triazole …

Tuberculosis (TB) is an infectious disease, infecting a quarter of world's population. Drug
resistant TB further exacerbates the grim scenario of the drying TB drug discovery pipeline …

Elevated aldehyde dehydrogenase (ALDH) activity correlates with poor outcome for many
solid tumors as ALDHs may regulate cell proliferation and chemoresistance of cancer stem …

Abstract Chitosan (Cs) bis-aldehyde Schiff base derivatives were synthesized by
condensation of Cs with three bis-aldehydes namely; butane-1, 4-diyl bis (4 …

A series of triazole conjugated novel 2, 5-diaryl 1, 3, 4-oxadiazole derivatives 8a-q are
efficiently synthesized starting from methyl salicylate. All the synthesized compounds were …

Tuberculosis (TB) is a major infectious disease associated increasingly with drug resistance.
Thus, new anti-tubercular agents with novel mechanisms of action are urgently required for …

Mycobacterium tuberculosis (MTB) is the causative agent of tuberculosis (TB), an ancient
disease which still today causes 1.4 million deaths worldwide per year. Long-term, multi …

Inosine 5′-monophosphate dehydrogenase (IMPDH) is a vital enzyme involved in the de
novo synthesis of guanine nucleotides. IMPDH catalyzes a crucial step of converting IMP …

The enzyme inosine 5′-monophosphate dehydrogenase (IMPDH) catalyzes an essential
step in the de novo biosynthesis of guanine nucleotides, and thus regulates the guanine …

Inosine 5ʹ‐monophosphate dehydrogenase (IMPDH) catalyzes a crucial step in the
biosynthesis of DNA and RNA, and it has been exploited as a promising target for …