Heart disease continues to be a significant clinical problem in Western society. Predictive
models and simulations that integrate physiological understanding with patient information …

In this chapter we introduce a combined parameter and model reduction methodology and
present its application to the efficient numerical estimation of a pressure drop in a set of …

Personalised computational models of the heart are of increasing interest for clinical
applications due to their discriminative and predictive abilities. However, the simulation of a …

The poikilothermic heart has been suggested as a model for studying some of the
mechanisms of early postnatal mammalian heart adaptations. We assessed morphological …

Cardiac hypertrophy is an adaption of the heart to a change in cardiovascular loading
conditions. The current understanding is that progression may be stress or strain driven, but …

Les survivants de leucémie lymphoblastique aigüe (LLA) sont à risque de développer une
insuffisance cardiaque à long terme à cause de l'effet cardiotoxique intrinsèque au …

We present recent investigations on the state of strain in human left ventricle based on the
synergy between continuum mechanics and echocardiographic imaging. When data from …

The pace of disease gene discovery is still much slower than expected, even with the use of
cost-effective DNA sequencing and genotyping technologies. It is increasingly clear that …

Personalised cardiac modeling consists in creating virtual 3D simulations of real clinical
cases to help clinicians predict the behaviour of the heart, or better understand some …

Gene regulation in humans and other mammalian organisms is complex with many different
layers. Despite huge advances in biomedical research, our ability to build a comprehensive …