Characterizing extracellular vesicles and their diverse RNA contents

EM Veziroglu, GI Mias - Frontiers in Genetics, 2020 - frontiersin.org
Cells release nanometer-scale, lipid bilayer-enclosed biomolecular packages (extracellular
vesicles; EVs) into their surrounding environment. EVs are hypothesized to be intercellular …

Viscoelastic microfluidics: Progress and challenges

J Zhou, I Papautsky - Microsystems & Nanoengineering, 2020 - nature.com
The manipulation of cells and particles suspended in viscoelastic fluids in microchannels
has drawn increasing attention, in part due to the ability for single-stream three-dimensional …

Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine

JC Contreras-Naranjo, HJ Wu, VM Ugaz - Lab on a Chip, 2017 - pubs.rsc.org
Exosomes, the smallest sized extracellular vesicles (∽ 30–150 nm) packaged with lipids,
proteins, functional messenger RNAs and microRNAs, and double-stranded DNA from their …

Field-free isolation of exosomes from extracellular vesicles by microfluidic viscoelastic flows

C Liu, J Guo, F Tian, N Yang, F Yan, Y Ding, JY Wei… - ACS …, 2017 - ACS Publications
Exosomes, molecular cargos secreted by almost all mammalian cells, are considered as
promising biomarkers to identify many diseases including cancers. However, the small size …

Inertial microfluidic physics

H Amini, W Lee, D Di Carlo - Lab on a Chip, 2014 - pubs.rsc.org
Microfluidics has experienced massive growth in the past two decades, and especially with
advances in rapid prototyping researchers have explored a multitude of channel structures …

Extracellular vesicles: techniques and biomedical applications related to single vesicle analysis

J Zhang, J Wu, G Wang, L He, Z Zheng, M Wu… - ACS …, 2023 - ACS Publications
Extracellular vesicles (EVs) are extensively dispersed lipid bilayer membrane vesicles
involved in the delivery and transportation of molecular payloads to certain cell types to …

Recent microfluidic advances in submicron to nanoparticle manipulation and separation

S Hettiarachchi, H Cha, L Ouyang, A Mudugamuwa… - Lab on a Chip, 2023 - pubs.rsc.org
Manipulation and separation of submicron and nanoparticles are indispensable in many
chemical, biological, medical, and environmental applications. Conventional technologies …

Particle manipulations in non-Newtonian microfluidics: A review

X Lu, C Liu, G Hu, X Xuan - Journal of colloid and interface science, 2017 - Elsevier
Microfluidic devices have been widely used since 1990s for diverse manipulations of
particles (a general term of beads, cells, vesicles, drops, etc.) in a variety of applications …

Nonlinear microfluidics

D Stoecklein, D Di Carlo - Analytical chemistry, 2018 - ACS Publications
Microfluidic flow is commonly employed in the biological, chemical, or physical analysis of
samples in small fluid volumes because of the typical lack of nonlinear phenomena, with …

Particle migration due to viscoelasticity of the suspending liquid and its relevance in microfluidic devices

G D'Avino, F Greco, PL Maffettone - Annual Review of Fluid …, 2017 - annualreviews.org
The fast growth of microfluidic applications based on complex fluids is a result of the unique
fluid dynamics of these systems, enabling the creation of devices for health care or …