Immune checkpoint therapy for solid tumours: clinical dilemmas and future trends
Q Sun, Z Hong, C Zhang, L Wang, Z Han… - Signal transduction and …, 2023 - nature.com
Abstract Immune-checkpoint inhibitors (ICBs), in addition to targeting CTLA-4, PD-1, and PD-
L1, novel targeting LAG-3 drugs have also been approved in clinical application. With the …
L1, novel targeting LAG-3 drugs have also been approved in clinical application. With the …
Sex disparities matter in cancer development and therapy
Curing cancer through precision medicine is the paramount aim of the new wave of
molecular and genomic therapies. Currently, whether patients with non-reproductive …
molecular and genomic therapies. Currently, whether patients with non-reproductive …
Sex differences in immunity
NM Wilkinson, HC Chen, MG Lechner… - Annual review of …, 2022 - annualreviews.org
Strong epidemiological evidence now exists that sex is an important biologic variable in
immunity. Recent studies, for example, have revealed that sex differences are associated …
immunity. Recent studies, for example, have revealed that sex differences are associated …
Human papillomavirus as a driver of head and neck cancers
ME Sabatini, S Chiocca - British journal of cancer, 2020 - nature.com
The human papillomavirus (HPV) family includes more than 170 different types of virus that
infect stratified epithelium. High-risk HPV is well established as the primary cause of cervical …
infect stratified epithelium. High-risk HPV is well established as the primary cause of cervical …
Association between body mass index and overall survival with immune checkpoint inhibitor therapy for advanced non–small cell lung cancer
G Kichenadasse, JO Miners, AA Mangoni… - JAMA …, 2020 - jamanetwork.com
Importance High body mass index (BMI) is independently associated with overall survival
benefit from immune checkpoint inhibitor therapy in patients with melanoma, yet whether …
benefit from immune checkpoint inhibitor therapy in patients with melanoma, yet whether …
Sex-associated molecular differences for cancer immunotherapy
Immune checkpoint blockade therapies have extended patient survival across multiple
cancer lineages, but there is a heated debate on whether cancer immunotherapy efficacy is …
cancer lineages, but there is a heated debate on whether cancer immunotherapy efficacy is …
Genome-wide sex and gender differences in cancer
CM Lopes-Ramos, J Quackenbush… - Frontiers in oncology, 2020 - frontiersin.org
Despite their known importance in clinical medicine, differences based on sex and gender
are among the least studied factors affecting cancer susceptibility, progression, survival, and …
are among the least studied factors affecting cancer susceptibility, progression, survival, and …
Sex differences in differentiated thyroid cancer
Background: Sex dimorphism strongly impacts tumor biology, with most cancers having a
male predominance. Uniquely, thyroid cancer (TC) is the only nonreproductive cancer with …
male predominance. Uniquely, thyroid cancer (TC) is the only nonreproductive cancer with …
Sex-based heterogeneity in response to lung cancer immunotherapy: a systematic review and meta-analysis
Background We previously showed that therapy with anti–checkpoints T-lymphocyte-
associated protein 4 (anti–CTLA-4) or antiprogrammed cell death protein 1 (anti–PD-1) …
associated protein 4 (anti–CTLA-4) or antiprogrammed cell death protein 1 (anti–PD-1) …
Single-cell RNA sequencing reveals the heterogeneity of tumor-associated macrophage in non-small cell lung cancer and differences between sexes
Non-Small Cell Lung Cancer (NSCLC) is a disease with high morbidity and mortality, which
has sex-related differences in prognosis and immunotherapy efficacy. However, the …
has sex-related differences in prognosis and immunotherapy efficacy. However, the …