Bacterial microcompartments (MCPs) are sophisticated protein-based organelles used to
optimize metabolic pathways. They consist of metabolic enzymes encapsulated within a …

Coenzyme B12 or adenosylcobalamin (AdoCbl)(Figure 1A), a naturally occurring
organometallic compound that contains a unique Co-C σ bond, serves as a cofactor for …

Cancers that appear pathologically similar often respond differently to the same drug
regimens. Methods to better match patients to drugs are in high demand. We demonstrate a …

The propanediol utilization (pdu) operon of Salmonella enterica serovar Typhimurium LT2
contains genes needed for the coenzyme B12-dependent catabolism of 1, 2-propanediol …

Lactobacillus reuteri is a heterofermentative lactic acid bacterium that naturally inhabits the
gut of humans and other animals. The probiotic effects of L. reuteri have been proposed to …

Hundreds of bacterial species produce proteinaceous microcompartments (MCPs) that act
as simple organelles by confining the enzymes of metabolic pathways that have toxic or …

The eut operon of Salmonella typhimurium encodes proteins involved in the cobalamin-
dependent degradation of ethanolamine. Previous genetic analysis revealed six eut genes …

Synthesis of cobalamin de novo by Salmonella enterica serovar Typhimurium strain LT2 and
the absence of this ability in Escherichia coli present several problems. This large synthetic …

Prokaryotes use subcellular compartments for a variety of purposes. An intriguing example
is a family of complex subcellular organelles known as bacterial microcompartments (MCP …

Sequencing-based studies have illuminated increased transcriptional complexity within the
genome structure of bacteria and have resulted in the identification of many small regulatory …