Dendritic cells (DCs) play an important role in advancing age-associated progressive
decline in adaptive immune responses, loss of tolerance, and development of chronic …

Improvements in tumor immunotherapies depend on better understanding of the anti-tumor
T cell response. By studying human tumor-draining lymph nodes (TDLNs), we found that …

As cancer immunotherapy continues to benefit from novel approaches which cut immune
'brake pedals'(eg anti-PD1 and anti-CTLA4 antibodies) and push immune cell gas pedals …

Presentation of exogenous antigens on MHC-I molecules, termed cross-presentation, is
essential for cytotoxic CD8+ T cell responses. In mice, dendritic cells (DCs) that arise from …

Abstract Systems vaccinology has defined molecular signatures and mechanisms of
immunity to vaccination. However, comparative analysis of immunity to different vaccines is …

As the capacity for generating large-scale molecular profiling data continues to grow, the
ability to extract meaningful biological knowledge from it remains a limitation. Here, we …

Background Regulatory dendritic cell (DC) markers, such as C1Q, are upregulated in
PBMCs of patients with grass pollen allergy exhibiting clinical benefit during allergen …

Dendritic cells (DCs) were initially defined as mononuclear phagocytes with a dendritic
morphology and an exquisite efficiency for naïve T-cell activation. DC encompass several …

Systems approaches for the study of immune signaling pathways have been traditionally
based on purified cells or cultured lines. However, in vivo responses involve the coordinated …

Transcriptomics, the high-throughput characterization of RNAs, has been instrumental in
defining pathogenic signatures in human autoimmunity and autoinflammation. It enabled the …