Vitamin A is a group of vital micronutrients widely present in the human diet. Animal-based
products are a rich source of the retinyl ester form of the vitamin, while vegetables and fruits …

T helper (Th) 17 cells are a subtype of CD4 T lymphocytes characterized by the expression
of retinoic acid-receptor (RAR)-related orphan receptor (ROR) γt transcription factor …

Without foreknowledge of the complete drug target information, development of promising
and affordable approaches for effective treatment of human diseases is challenging. Here …

Research in the pathogenesis of inflammatory skin diseases, such as skin dermatitis and
psoriasis, has experienced some relevant breakthroughs in recent years. The understanding …

The androgen receptor (AR) is overexpressed and hyperactivated in human castration-
resistant prostate cancer (CRPC). However, the determinants of AR overexpression in …

Whether the retinoic acid-related orphan receptor (ROR) is a nuclear receptor of melatonin
remains controversial. ROR is inextricably linked to melatonin in terms of its expression …

Circadian rhythm disruption or decrease in levels of circadian hormones such as melatonin
increases ischemic heart disease risk. The nuclear melatonin receptors ROR s are pivotally …

Pregnancy is influenced by the circadian (“circa” or approximately; diēm or day) system,
which coordinates physiology and behavior with predictable daily changes in the …

Human cerebellar development is orchestrated by molecular regulatory networks to achieve
cytoarchitecture and coordinate motor and cognitive functions. Here, we combined single …

Retinoic acid–related orphan receptor γt (RORγt) functions as a ligand-dependent
transcription factor that regulates multiple proinflammatory genes and plays a critical role in …