Genome Wide Association Studies (GWAS) have mapped thousands of genetic variants
associated with complex disease risk and regulating quantitative traits, thus exploiting an …

Hypercholesterolemia is a strong determinant of mortality and morbidity associated with
cardiovascular diseases and a major contributor to the global disease burden. Mutations in …

Large-scale meta-analyses of genome-wide association studies (GWAS) have identified>
175 loci associated with fasting cholesterol levels, including total cholesterol (TC), high …

Implementing precision medicine for complex diseases such as chronic obstructive lung
disease (COPD) will require extensive use of biomarkers and an in-depth understanding of …

Metabolic syndrome (MetS), a cluster of metabolic disturbances that increase the risk for
cardiovascular disease and diabetes, was because of genetic susceptibility and …

Abstract Purpose of Review An abnormal lipid profile is considered a main risk factor for
cardiovascular diseases and evidence suggests that single nucleotide polymorphisms …

Background—Multiple genetic loci associated with lipid levels have been identified
predominantly in Europeans, and the issue of to what extent these genetic loci can predict …

Background There is growing interest in the hypertriglyceridemic waist (HTGW) phenotype,
defined as high waist circumference (≥ 95 cm in males and≥ 80 cm in females) combined …

The practical pharmacogenetics of Alzheimer's disease (AD) is circumscribed to
acetylcholinesterase inhibitors (AChEIs) and memantine. However, pharmacogenetic …

Inbred mice exhibit strain-specific variation in susceptibility to atherosclerosis and
dyslipidemia that renders them useful in dissecting the genetic architecture of these complex …