Neuroplastin in human cognition: review of literature and future perspectives
Synaptic glycoprotein neuroplastin is involved in synaptic plasticity and complex molecular
events underlying learning and memory. Studies in mice and rats suggest that neuroplastin …
events underlying learning and memory. Studies in mice and rats suggest that neuroplastin …
[HTML][HTML] Dynamic compartmentalization of calcium channel signalling in neurons
M Heine, J Heck, A Ciuraszkiewicz, A Bikbaev - Neuropharmacology, 2020 - Elsevier
Calcium fluxes through the neuronal membrane are strictly limited in time due to biophysical
properties of voltage-gated and ligand-activated ion channels and receptors. Being …
properties of voltage-gated and ligand-activated ion channels and receptors. Being …
The amino-terminal domain of GluA1 mediates LTP maintenance via interaction with neuroplastin-65
CH Jiang, M Wei, C Zhang… - Proceedings of the …, 2021 - National Acad Sciences
Long-term potentiation (LTP) has long been considered as an important cellular mechanism
for learning and memory. LTP expression involves NMDA receptor-dependent synaptic …
for learning and memory. LTP expression involves NMDA receptor-dependent synaptic …
The two faces of synaptic failure in AppNL-GF knock-in mice
A Latif-Hernandez, V Sabanov, T Ahmed… - Alzheimer's research & …, 2020 - Springer
Background Intensive basic and preclinical research into Alzheimer's disease (AD) has
yielded important new findings, but they could not yet been translated into effective …
yielded important new findings, but they could not yet been translated into effective …
Early sensory experience influences the development of multisensory thalamocortical and intracortical connections of primary sensory cortices
JU Henschke, AM Oelschlegel, F Angenstein… - Brain Structure and …, 2018 - Springer
The nervous system integrates information from multiple senses. This multisensory
integration already occurs in primary sensory cortices via direct thalamocortical and …
integration already occurs in primary sensory cortices via direct thalamocortical and …
[HTML][HTML] Ca2+ signaling in postsynaptic neurons: Neuroplastin-65 regulates the interplay between plasma membrane Ca2+ ATPases and ionotropic glutamate …
Upon postsynaptic glutamate receptor activation, the cytosolic Ca 2+ concentration rises and
initiates signaling and plasticity in spines. The plasma membrane Ca 2+ ATPase (PMCA) is …
initiates signaling and plasticity in spines. The plasma membrane Ca 2+ ATPase (PMCA) is …
A complex of Neuroplastin and Plasma Membrane Ca2+ ATPase controls T cell activation
M Korthals, K Langnaese, KH Smalla, T Kähne… - Scientific reports, 2017 - nature.com
The outcome of T cell activation is determined by mechanisms that balance Ca2+ influx and
clearance. Here we report that murine CD4 T cells lacking Neuroplastin (Nptn−/−), an …
clearance. Here we report that murine CD4 T cells lacking Neuroplastin (Nptn−/−), an …
A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice
S Barendrecht, A Schreurs, S Geissler… - Alzheimer's Research & …, 2023 - Springer
Background Hyperphosphorylation and intraneuronal aggregation of the microtubule-
associated protein tau is a major pathological hallmark of Alzheimer's disease (AD) brain. Of …
associated protein tau is a major pathological hallmark of Alzheimer's disease (AD) brain. Of …
Plasma membrane calcium ATPase-neuroplastin complexes are selectively stabilized in GM1-containing lipid rafts
The recent identification of plasma membrane (Ca2+)-ATPase (PMCA)-Neuroplastin (Np)
complexes has renewed attention on cell regulation of cytosolic calcium extrusion, which is …
complexes has renewed attention on cell regulation of cytosolic calcium extrusion, which is …
Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration
The cell adhesion molecule neuroplastin (Np) is a novel candidate to influence human
intelligence. Np-deficient mice display complex cognitive deficits and reduced levels of …
intelligence. Np-deficient mice display complex cognitive deficits and reduced levels of …