The clinical manifestation of metastasis in a vital organ is the final stage of cancer
progression and the main culprit of cancer-related mortality. Once established, metastasis is …

Metastasis is powered by disseminated cancer cells that re-create a full-fledged tumor in
unwelcoming tissues, away from the primary site. How cancer cells moving from a tumor into …

Tumor evolution is driven by the progressive acquisition of genetic and epigenetic
alterations that enable uncontrolled growth and expansion to neighboring and distal tissues …

The cell type specific sequences of transcriptional programs during lung regeneration have
remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model …

Tyrosine kinase inhibitors were found to be clinically effective for treatment of patients with
certain subsets of cancers carrying somatic mutations in receptor tyrosine kinases. However …

Despite recent efforts to dissect the inter-tumor heterogeneity of pancreatic ductal
adenocarcinoma (PDAC) by determining prognosis-predictive gene expression signatures …

During the progression of pancreatic ductal adenocarcinoma (PDAC), heterogeneous
subclonal populations emerge that drive primary tumor growth, regional spread, distant …

As the culprit behind most cancer-related deaths, metastasis is the ultimate challenge in our
effort to fight cancer as a life-threatening disease. The explosive growth of metastasis …

How cancer cells acquire the competence to colonize distant organs remains a central
question in cancer biology. Tumors can release large numbers of cancer cells into the …

Primary tumors are known to constantly shed a large number of cancer cells into systemic
dissemination, yet only a tiny fraction of these cells is capable of forming overt metastases …