Oligodendrocyte precursor cells (OPCs) account for 5% of the resident parenchymal central
nervous system glial cells. OPCs are not only a back-up for the loss of oligodendrocytes that …

The restoration of myelin sheaths on demyelinated axons remains a major obstacle in the
treatment of multiple sclerosis (MS). Currently approved therapies work by modulating the …

Microglia are highly plastic immune cells which exist in a continuum of activation states. By
shaping the function of oligodendrocyte precursor cells (OPCs), the brain cells which …

Altered myelin structure and oligodendrocyte function have been shown to correlate with
cognitive and motor dysfunction and deficits in social behavior. We and others have …

Nervous system function depends on proper myelination for insulation and critical trophic
support for axons. Myelination is tightly regulated spatially and temporally, but how it is …

Prior studies support a role for mammalian target of rapamycin (mTOR) signaling in
oligodendrocyte differentiation and myelination. Here we use Cre-recombinase driven by …

The mammalian target of rapamycin (mTOR) pathway integrates multiple signals and
regulates crucial cell functions via the molecular complexes mTORC1 and mTORC2. These …

Objectives To systematically review findings of GWAS in schizophrenia (SZ) and in bipolar
disorder (BD); and to interpret findings, with a focus on identifying independent replications …

Oligodendrocytes enwrap central nervous system axons with myelin, a lipid enriched highly
organized multi-layer membrane structure that allows for fast long-distance saltatory …

Multiple extracellular and intracellular signals regulate the functions of oligodendrocytes as
they progress through the complex process of developmental myelination and then maintain …