ESCRT disruption provides evidence against trans-synaptic signaling via extracellular vesicles

EC Dresselhaus, KP Harris, CR Blanchette… - Journal of Cell …, 2024 - rupress.org
Extracellular vesicles (EVs) are released by many cell types, including neurons, carrying
cargoes involved in signaling and disease. It is unclear whether EVs promote intercellular …

Tunneling Nanotubes in the Brain

D Budinger, V Baker, MT Heneka - Intercellular and Interorganellar …, 2024 - Springer
Tunneling nanotubes (TNTs) have emerged as intriguing structures facilitating intercellular
communications across diverse cell types, which are integral to several biological …

Enhancing fat graft survival: thymosin beta-4 facilitates mitochondrial transfer from ADSCs via tunneling nanotubes by upregulating the Rac/F-actin pathway

X Zhang, Y Lin, H Li, Q Wang, D Mu - Free Radical Biology and Medicine, 2025 - Elsevier
Autologous fat grafting is a widely used technique in plastic and reconstructive surgery, but
its efficacy is often limited by the poor survival rate of transplanted adipose tissue. This study …

Pericyte-to-endothelial cell communication via tunneling nanotubes is disrupted by a diol of docosahexaenoic acid

S Kempf, R Popp, Z Naeem, T Frömel, I Wittig, S Klatt… - Cells, 2024 - pmc.ncbi.nlm.nih.gov
The pericyte coverage of microvessels is altered in metabolic diseases, but the mechanisms
regulating pericyte–endothelial cell communication remain unclear. This study investigated …

Novel genes involved in vascular dysfunction of the middle temporal gyrus in Alzheimer's disease: transcriptomics combined with machine learning analysis

M Wang, A He, Y Kang, Z Wang, Y He… - Neural Regeneration …, 2025 - journals.lww.com
Studies have shown that vascular dysfunction is closely related to the pathogenesis of
Alzheimer's disease. The middle temporal gyrus region of the brain is susceptible to …

Tunneling Nanotubes: The Cables for Viral Spread and Beyond

D Kapoor, P Sharma, A Saini, E Azhar, J Elste… - … and Communication in …, 2024 - Springer
Multicellular organisms require cell-to-cell communication to maintain homeostasis and
thrive. For cells to communicate, a network of filamentous, actin-rich tunneling nanotubes …

ESCRT disruption provides evidence against transsynaptic signaling functions for extracellular vesicles

EC Dresselhaus, KP Harris, CR Blanchette, K Koles… - …, 2024 - pmc.ncbi.nlm.nih.gov
Extracellular vesicles (EVs) are released by many cell types including neurons, carrying
cargoes involved in signaling and disease. It is unclear whether EVs promote intercellular …

Neurovascular unit adjustments following chronic distress explain motivational deficits in mice

L Cabeza, D Mor, B Ramadan, G Benhora-Chabeaux… - bioRxiv, 2024 - biorxiv.org
Background. The neurovascular unit (NVU) represents the structural and functional
relationship between the neural tissue and the blood. Neurovascular dysfunction has been …

Rivelare il potenziale delle vescicole extracellulari astrocitarie: una nuova frontiera per potenziare la riparazione cerebrale nella malattia di Parkinson

G Paterno - 2024 - tesidottorato.depositolegale.it
Parkinson's disease (PD) is the second most common neurodegenerative disorder after
Alzheimer's disease, defined by motor and non-motor symptoms. The degenerative process …