Abstract The three-dimensional (3D) multicellular tumor spheroids (MCTs) model is
becoming an essential tool in cancer research as it expresses an intermediate complexity …

Simple Summary Metastasis, the process by which cancer cells escape primary tumor site
and colonize distant organs, is responsible for most cancer-related deaths. The tumor …

The extracellular matrix is perturbed in tumors. The tumor matrix promotes the growth,
survival, and invasion of the cancer and modifies fibroblast and immune cell behavior to …

Physical forces have a crucial role in tumor progression and cancer treatment. The
application of principles of engineering and physical sciences to oncology has provided …

Metastasis is a multistep process in which tumor extracellular matrix (ECM) and cancer cell
cytoskeleton interactions are pivotal. ECM is connected, through integrins, to the cell's …

Pancreatic ductal adenocarcinoma (PDAC) belongs to the most lethal solid tumors in
humans. A histological hallmark feature of PDAC is the pronounced tumor microenvironment …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Solid tumors are characterized by an abnormal stroma that contributes to the development of
biomechanical abnormalities in the tumor microenvironment. In particular, these …

Cells in tissues experience a plethora of forces that regulate their fate and modulate
development and homeostasis. Cells sense mechanical cues through localized …

Cells respond to both chemical and mechanical cues present within their microenvironment.
Various mechanical signals are detected by and transmitted to the cells through …