Cysteamine hydrochloride affects ocular development and triggers associated inflammation in zebrafish

C Chen, Y Zuo, H Hu, Y Shao, S Dong, J Zeng… - Journal of Hazardous …, 2023 - Elsevier
The increasing use of cosmetics has raised widespread concerns regarding their
ingredients. Cysteamine hydrochloride (CSH) is a newly identified allergenic component in …

Factors associated with elevated tumor necrosis factor-α in aqueous humor of patients with open-angle glaucoma

Y Jung, K Ohn, H Shin, SE Oh, CK Park… - Journal of Clinical …, 2022 - mdpi.com
Tumor necrosis factor-alpha (TNF-α) is an important modulator of neuroinflammation,
secreted from activated glial cells in response to intraocular stress. The purpose of this study …

Effects of different alkylating agents on photoreceptor degeneration and proliferative response of Müller glia

K Nomura-Komoike, R Nishino, H Fujieda - Scientific Reports, 2024 - nature.com
Animal models for retinal degeneration are essential for elucidating its pathogenesis and
developing new therapeutic strategies in humans. N-methyl-N-nitrosourea (MNU) has been …

Eye Drop with Fas-Blocking Peptide Attenuates Age-Related Macular Degeneration

Y Yi, SH Pyun, CY Kim, G Yun, E Kang, S Heo, I Ullah… - Cells, 2024 - mdpi.com
Age-related macular degeneration (AMD), characterized by macular retinal degeneration,
poses a significant health concern due to the lack of effective treatments for prevalent dry …

Fluoxetine Protects Retinal Ischemic Damage in Mice

GL Romano, L Gozzo, OM Maurel, S Di Martino… - Pharmaceutics, 2023 - mdpi.com
Background: To evaluate the neuroprotective effect of the topical ocular administration of
fluoxetine (FLX) in a mouse model of acute retinal damage. Methods: Ocular …

[HTML][HTML] Identification of Optic Nerve–Related Biomarkers in Primary Open-Angle Glaucoma Based on Comprehensive Bioinformatics and Mendelian Randomization

S Zhao, Q Dai, Z Rao, J Li, A Wang… - … Vision Science & …, 2024 - iovs.arvojournals.org
Purpose: Glaucoma is the primary cause of permanent vision loss worldwide. However, the
pathogenesis of primary open-angle glaucoma (POAG), the main type of glaucoma, has not …

Silencing circRUFY1 protects retinal ganglion cell injury in acute intraocular hypertension by activating the ERK pathway through miR-196a-5p/CALM3 axis

BB Li, SJ Li, W Tang, M Zeng - Molecular & Cellular Toxicology, 2024 - Springer
Background Neuroinflammation has been recognized as a key pathological event in acute
glaucoma. Medical treatment of acute glaucoma has mainly focused on lowering intraocular …

[PDF][PDF] Fluoxetine Protects Retinal Ischemic Damage in Mice. Pharmaceutics 2023, 15, 1370

GL Romano, L Gozzo, OM Maurel, S Di Martino… - 2023 - researchgate.net
Background: To evaluate the neuroprotective effect of the topical ocular administration of
fluoxetine (FLX) in a mouse model of acute retinal damage. Methods: Ocular …

Temporal relationships between photoreceptor degeneration and proliferative response of Müller glia: A comparative study on the effects of different alkylating agents

K Nomura-Komoike, R Nishino, H Fujieda - 2023 - researchsquare.com
Animal models for retinal degeneration are essential for elucidating its pathogenesis and
developing new therapeutic strategies in humans. N-methyl-N-nitrosourea (MNU) has been …