Nearly 7 decades have elapsed since Francis Crick introduced the central dogma of
molecular biology, as part of his ideas on protein synthesis, setting the fundamental rules of …

Transcriptional enhancers are regulatory DNA elements that underlie the specificity and
dynamic patterns of gene expression. Over the past decade, large-scale functional …

Abstract The three-dimensional (3D) structure of chromatin is intrinsically associated with
gene regulation and cell function,–. Methods based on chromatin conformation capture have …

Epilepsy is a neurological disease characterized by repeated seizures. Despite of that the
brain-derived neurotrophic factor (BDNF) is implicated in the pathogenesis of …

Wounds in diabetic patients, especially diabetic foot ulcers, are more difficult to heal
compared with normal wounds and can easily deteriorate, leading to amputation. Common …

Activity-driven transcription is a key event associated with long-lasting forms of neuronal
plasticity. Despite the efforts to investigate the regulatory mechanisms that control this …

Neurons are dynamic cells that respond and adapt to stimuli throughout their long
postmitotic lives. The structural and functional plasticity of neurons requires the regulated …

Methyl CpG binding protein 2 (MeCP2) was first identified as a nuclear protein with a
transcriptional repressor role that recognizes DNA methylation marks. MeCP2 has a well …

Recent burst of new technologies that allow for quantitatively delineating chromatin structure
has greatly expanded our understanding of how the genome is organized in the three …

The mammalian nucleus is compartmentalized by diverse subnuclear structures. These
subnuclear structures, marked by nuclear bodies and histone modifications, are often cell …