Lost in translation: Inconvenient truths on the utility of mouse models in Alzheimer's disease research
The recent, controversial approval of antibody-based treatments for Alzheimer's disease
(AD) is fueling a heated debate on the molecular determinants of this condition. The …
(AD) is fueling a heated debate on the molecular determinants of this condition. The …
Increased expression of the proapoptotic presenilin associated protein is involved in neuronal tangle formation in human brain
C Yang, ZP Sun, J Jiang, XL Cai, Y Wang, H Wang… - Scientific Reports, 2024 - nature.com
Presenilin-associated protein (PSAP) is a mitochondrial proapoptotic protein as established
in cell biology studies. It remains unknown whether it involves in neurodegenerative …
in cell biology studies. It remains unknown whether it involves in neurodegenerative …
[HTML][HTML] Myeloid-derived β-hexosaminidase is essential for neuronal health and lysosome function: implications for Sandhoff disease
Lysosomal storage disorders (LSDs) are a large disease class involving lysosomal
dysfunction, often resulting in neurodegeneration. Sandhoff disease (SD) is an LSD caused …
dysfunction, often resulting in neurodegeneration. Sandhoff disease (SD) is an LSD caused …