Biofilms are multicellular microbial aggregates that can be associated with host mucosal
epithelia in the airway, gut, and genitourinary tract. The host environment plays a critical role …

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality
worldwide. COPD heterogeneity has hampered progress in developing pharmacotherapies …

Summary Background Alpha-1 Antitrypsin (AAT) deficiency (AATD), the most common
genetic cause of emphysema presents with unexplained phenotypic heterogeneity in …

SUMMARY OF KEY POINTS International respiratory organizations now recommend using
lower limit of normal and standardized residuals to diagnose airflow obstruction and COPD …

The onset of chronic obstructive pulmonary disease (COPD) is heterogeneous, and current
approaches to define distinct disease phenotypes are lacking. In addition to clinical …

Introduction Alpha1 antitrypsin deficiency (AATD), a common hereditary disorder affecting
mainly lungs, liver and skin has been the focus of some of the most exciting therapeutic …

Background: Bronchoscopic lung volume reduction using one-way endobronchial valves
(EBVs) is a valid therapy for severe emphysema patients. However, alpha-1 antitrypsin …

Cardiovascular diseases (CVD) are diverse disorders affecting the heart and vasculature in
millions of people worldwide. Like other fields, CVD research has benefitted from the deluge …

Abstract Purpose A 1 Antitrypsin deficiency (AATD) pathogenic mutations are expanding
beyond the PI* Z and PI* S to a multitude of rare variants. Aim to investigate genotype and …

Background Alpha-1 antitrypsin deficiency is an under-recognized genetic cause of chronic
lung and liver disease; it remains unclear what the testing frequency and disparities are for …