The pathogenesis of tuberculous meningitis
AG Davis, UK Rohlwink, A Proust… - Journal of leukocyte …, 2019 - academic.oup.com
Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the
brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM) …
brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM) …
Bacterial meningitis in Africa
Bacterial meningitis differs globally, and the incidence and case fatality rates vary by region,
country, pathogen, and age group; being a life-threatening disease with a high case fatality …
country, pathogen, and age group; being a life-threatening disease with a high case fatality …
Dynamic PET reveals compartmentalized brain and lung tissue antibiotic exposures of tuberculosis drugs
Tuberculosis (TB) remains a leading cause of death, but antibiotic treatments for tuberculous
meningitis, the deadliest form of TB, are based on those developed for pulmonary TB and …
meningitis, the deadliest form of TB, are based on those developed for pulmonary TB and …
A phase 2A trial of the safety and tolerability of increased dose rifampicin and adjunctive linezolid, with or without aspirin, for human immunodeficiency virus …
Background Drug regimens that include intensified antibiotics alongside effective anti-
inflammatory therapies may improve outcomes in tuberculous meningitis (TBM). Safety data …
inflammatory therapies may improve outcomes in tuberculous meningitis (TBM). Safety data …
Cognitive impairment in tuberculous meningitis
Background Cognitive impairment is reported as a common complication in adult
tuberculous meningitis (TBM), yet few studies have systematically assessed the frequency …
tuberculous meningitis (TBM), yet few studies have systematically assessed the frequency …
Linezolid does not improve bactericidal activity of rifampin-containing first-line regimens in animal models of TB meningitis
Tuberculous meningitis (TB meningitis) is the most devastating form of tuberculosis (TB) and
there is a critical need to optimize treatment. Linezolid is approved for multidrug resistant TB …
there is a critical need to optimize treatment. Linezolid is approved for multidrug resistant TB …
Linezolid population pharmacokinetic model in plasma and cerebrospinal fluid among patients with tuberculosis meningitis
N Abdelgawad, S Wasserman… - The Journal of …, 2024 - academic.oup.com
Background Linezolid is evaluated in novel treatment regimens for tuberculous meningitis
(TBM). Linezolid pharmacokinetics have not been characterized in this population …
(TBM). Linezolid pharmacokinetics have not been characterized in this population …
Validation of a quantitative liquid chromatography tandem mass spectrometry assay for linezolid in cerebrospinal fluid and its application to patients with HIV …
M Mazanhanga, A Joubert, S Castel, M Van de Merwe… - Heliyon, 2023 - cell.com
Tuberculous meningitis treatment outcomes are poor and alternative regimens are under
investigation. Reliable methods to measure drug concentrations in cerebrospinal fluid are …
investigation. Reliable methods to measure drug concentrations in cerebrospinal fluid are …
[HTML][HTML] Dynamic PET Reveals Compartmentalized Brain and Lung Tissue Antibiotic Exposures
Tuberculosis (TB) remains a leading cause of death, but antibiotic treatments for tuberculous
meningitis, the deadliest form of TB, are based on those developed for pulmonary TB and …
meningitis, the deadliest form of TB, are based on those developed for pulmonary TB and …
[PDF][PDF] Treatment and Toxicity Considerations in Tuberculosis: A Narrative Review
NT Jones, R Abadie, CL Keller, K Jones, LF Ledet III… - Cureus, 2024 - cureus.com
Tuberculosis remains one of the most significant bacterial infections plaguing the medical
community worldwide. The bacteria Mycobacterium tuberculosis retains the ability to …
community worldwide. The bacteria Mycobacterium tuberculosis retains the ability to …