Ketamine, a commonly used general anesthetic, can produce rapid and sustained
antidepressant effect. However, the efficacy and safety of the perioperative application of …

Ketamine's clinical use began in the 1970s. Physicians benefited from its safety and ability to
induce short-term anesthesia and analgesia. The psychodysleptic effects caused by the …

BACKGROUND: IV ketamine is widely used to treat patients with chronic pain, yet the long-
term impact remains uncertain. We synthesized evidence from randomized control trials to …

Ketamine is commonly used as an analgesic in emergency medicine and as an adjuvant
drug in the perioperative setting. In addition, it is used as a third-line adjuvant drug for opioid …

Ketamine, a nonselective NMDA receptor antagonist, is used widely in medicine as an
anesthetic agent. However, ketamine's mechanisms of action lead to widespread …

Background: Ketamine is often used for the management of refractory chronic pain. There is,
however, a paucity of trials exploring its analgesic effect several weeks after intravenous …

Pain disorders and psychiatric illness are strongly comorbid, particularly in the context of
Major Depressive Disorder (MDD). While these disorders account for a significant amount of …

In Part I of this series, we provide guidance for preparing a systematic review protocol. In this
article, we highlight important steps and supplement with exemplars on conducting and …

Introduction: Chronic neuropathic pain (NP) is an incapacitating illness caused by a lesion of
the somatosensory nervous system and is associated with several diseases or syndromes …

The term 'adjuvant analgesics' was originally applied to drugs that were approved for
indications other than pain but were useful as coanalgesics during opioid therapy. During …