Nucleobase editors comprising nucleic acid programmable DNA binding proteins
2019-03-13 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
AAV delivery of nucleobase editors
DR Liu, JM Levy, WH Yeh - US Patent 11,306,324, 2022 - Google Patents
2018-02-22 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
Evolution of site-specific recombinases
DR Liu, DB Thompson, JL Bessen - US Patent 10,392,674, 2019 - Google Patents
Some aspects of the present disclosure provide methods for evolving recombinases to
recognize target sequences that differ from the canonical recognition sequences. Some …
recognize target sequences that differ from the canonical recognition sequences. Some …
Evolved cas9 proteins for gene editing
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that
are useful for engineering Cas9 and Cas9 variants that have increased activity on target …
are useful for engineering Cas9 and Cas9 variants that have increased activity on target …
Negative selection and stringency modulation in continuous evolution systems
(57) ABSTRACT Strategies, systems, methods, reagents, and kits for phage assisted
continuous evolution are provided herein. These include strategies, systems, methods …
continuous evolution are provided herein. These include strategies, systems, methods …
Evolution of site-specific recombinases
DR Liu, DB Thompson, JL Bessen - US Patent 11,104,967, 2021 - Google Patents
Some aspects of the present disclosure provide methods for evolving recombinases to
recognize target sequences that differ from the canonical recognition sequences. Some …
recognize target sequences that differ from the canonical recognition sequences. Some …
Continuous directed evolution
The invention provides systems, methods, reagents, apparatuses, vectors, and host cells for
the continuous evolution of nucleic acids. For example, a lagoon is provided in which a …
the continuous evolution of nucleic acids. For example, a lagoon is provided in which a …