Magnetic nanoparticles have received tremendous attention in diverse fields because of
their unique nanoscale physicochemical properties and the potential for a wide range of …

Since the discovery of its facile synthesis in 2001, meso-aryl-substituted expanded
porphyrins have been developed as a new class of azaannulenes in light of their facile …

Platinum-containing drugs (eg, cisplatin) are among the most frequently used
chemotherapeutic agents. Their tremendous success has spurred research and …

The use of planar or tridimensional cyclic and acyclic Schiff bases, their polyamine
homologues and related derivatives, for the formation of mononuclear and especially …

Introduction 2.1. The Biology 2.2. Reactive Oxygen Species (ROS) in Oncology 2.3. Cellular
Defense of ROS 3. Pre-Clinical Data 3.1. Buthionine sulfoximine 3.2. Ascorbic acid 3.3 …

Motexafin gadolinium (MGd, Xcytrin®) is an aromatic macrocycle that has a strong affinity for
electrons, ie, it is easily reduced. In the presence of oxygen, MGd accepts electrons from …

Described here is the development of gadolinium (III) texaphyrin-platinum (IV) conjugates
capable of overcoming platinum resistance by 1) localizing to solid tumors, 2) promoting …

The successful treatment of melanoma has been hampered by the unique biology of this
cancer. Fortunately, research to further our understanding of how melanoma cells differ from …

Motexafin gadolinium (MGd), an expanded porphyrin, is a tumor-selective redox-mediator
that reacts with many intracellular reducing metabolites. Because redox mechanisms …

In the previous publication, some of us reported the conversion of a copper (I) complex to a
copper (II) oxalate complex, and claimed that this conversion involved a reduction of CO2 to …