Mechanical hallmarks of fibrotic microenvironments are both outcomes and causes of
fibrosis progression. Understanding how cells sense and transmit mechanical cues in the …

The intact heart undergoes complex and multiscale remodelling processes in response to
altered mechanical cues. Remodelling of the myocardium is regulated by a combination of …

Comprehensive molecular‐level models of human metabolism have been generated on a
cellular level. However, models of whole‐body metabolism have not been established as …

Pathological cardiac hypertrophy is a key risk factor for the development of heart failure and
predisposes individuals to cardiac arrhythmia and sudden death. While physiological …

Prolonged QT intervals are a major risk factor for ventricular arrhythmias and a leading
cause of sudden cardiac death. Various drugs are known to trigger QT interval prolongation …

Patient-specific cardiac models are now being used to guide therapies. The increased use
of patient-specific cardiac simulations in clinical care will give rise to the development of …

Arterial growth and remodeling at the tissue level is driven by mechanobiological processes
at cellular and sub-cellular levels. Although it is widely accepted that cells seek to promote …

The mechanical environment and anisotropic structure of the heart modulate cardiac
function at the cellular, tissue and organ levels. During myocardial infarction (MI) and …

Tissue-level biomechanical properties and function derive from underlying cell signaling,
which regulates mass deposition, organization, and removal. Here, we couple two existing …

Pulmonary arterial adventitial fibroblasts (PAAFs) are important regulators of fibrotic vascular
remodeling during the progression of pulmonary arterial hypertension (PAH), a disease that …