Lipids entering the gastrointestinal tract include dietary lipids (triacylglycerols, cholesteryl
esters and phospholipids) and endogenous lipids from bile (phospholipids and cholesterol) …

Fatty acids are the most efficient substrates for energy production in vertebrates and are
essential components of the lipids that form biological membranes. Synthesis of …

Lipophagy is defined as the autophagic degradation of intracellular lipid droplets (LDs).
While the field of lipophagy research is relatively young, an expansion of research in this …

Elevated circulating fatty acids (FAs) contribute to the development of obesity-associated
metabolic complications such as insulin resistance (IR) and non-alcoholic fatty liver disease …

Digested dietary fats are taken up by enterocytes where they are assembled into pre-
chylomicrons in the endoplasmic reticulum followed by transport to the Golgi for maturation …

Adipose triglyceride lipase (ATGL) has been discovered 14 years ago and revised our view
on intracellular triglyceride (TG) mobilization–a process termed lipolysis. ATGL initiates the …

The term lipophagy is used to describe the autophagic degradation of lipid droplets, the
main lipid storage organelles of eukaryotic cells. Ever since its discovery in 2009, lipophagy …

Sirtuin 1 (SIRT1), an NAD+-dependent protein deacetylase, regulates a host of target
proteins, including peroxisome proliferator–activated receptor (PPAR)-γ coactivator-1α (PGC …

The incidence of obesity and associated metabolic diseases is increasing globally,
adversely affecting human health. Dietary fats, especially triglycerides, are an important …

Dietary fat provides essential nutrients, contributes to energy balance, and regulates blood
lipid concentrations. These functions are important to health, but can also become …