The calyx of Held is an axosomatic terminal in the auditory brainstem that has attracted
anatomists because of its giant size and physiologists because of its accessibility to patch …

Spontaneous electrical activity is a common feature of sensory systems during early
development. This sensory-independent neuronal activity has been implicated in promoting …

Action potential timing is fundamental to information processing; however, its determinants
are not fully understood. Here we report unexpected structural specializations in the Ranvier …

Plasticity of myelination represents a mechanism to tune the flow of information by balancing
functional requirements with metabolic and spatial constraints. The auditory system is …

Action potentials invading the presynaptic terminal trigger discharge of docked synaptic
vesicles (SVs) by opening voltage-dependent calcium channels (CaVs) and admitting …

Hallmark features of neural circuit development include early exuberant innervation followed
by competition and pruning to mature innervation topography. Several neural systems …

Key points• Following release of glutamate from excitatory synapses, excitatory amino acid
transporters (EAATs) sequester this glutamate into neighbouring astrocytes.• The signalling …

Acoustic communication requires gathering, transforming, and interpreting diverse sound
cues. To achieve this, all the spatial and temporal features of complex sound stimuli must be …

Key points The proteoglycan brevican is a major component of the extracellular matrix of
perineuronal nets and is highly enriched in the perisynaptic space suggesting a role for …

Perineuronal nets (PNs) are matrix molecule assemblies surrounding neuronal somata,
dendrites and axon initial segments in a lattice-like appearance. PN molecules are involved …