Abstract Beta-endorphin (β-END) is an opioid neuropeptide which has an important role in
the development of hypotheses concerning the non-synaptic or paracrine communication of …

Gene therapy for neurological disorder is currently an experimental concept. The goals for
clinical utilization are the relief of symptoms, slowing of disease progression, and correction …

Gene therapy for the control of pain has, to date, targeted neurons. However, recent
evidence supports that spinal cord glia are critical to the creation and maintenance of pain …

Objective To improve the understanding of chronic pelvic pain (CPP) and to provide
evidence-based guidelines of value to primary care health professionals, general …

Objective: Preclinical evidence indicates that gene transfer to the dorsal root ganglion using
replication‐defective herpes simplex virus (HSV)‐based vectors can reduce pain‐related …

Background Gene transfer to nociceptive neurons of the dorsal root ganglia (DRG) is a
promising approach to dissect mechanisms of pain in rodents and is a potential therapeutic …

Endogenous opiate peptides acting pre-and post-synaptically in the dorsal horn of spinal
cord inhibit transmission of nociceptive stimuli. We transfected neurons of the dorsal root …

Background: Neuronal transduction by adeno-associated viral (AAV) vectors has been
demonstrated in cortex, brainstem, cerebellum, and sensory ganglia. Intrathecal delivery of …

Rheumatoid arthritis is characterized by erosive inflammation of the joints, new bone
proliferation, and ankylosis, leading to severely reduced locomotion and intense chronic …

Lumbar puncture (LP) is an attractive route to deliver drugs to the nervous system because it
is a safe bedside procedure. Its use for gene therapy has been complicated by poor vector …