Fibrosis is defined as a fibroproliferative or abnormal fibroblast activation‐related disease.
Deregulation of wound healing leads to hyperactivation of fibroblasts and excessive …

In liver tissue matrix metalloproteinases (MMPs) and their specific inhibitors (tissue inhibitors
of metalloproteinases, TIMPs) play a pivotal role in both, fibrogenesis and fibrolysis. The …

Following chronic liver injury of any etiology, there is progressive fibrosis. To date, removing
the causative agent is the only effective therapy to stop or even reverse liver fibrosis …

Background/Aims: Our group has been involved in searching for different strategies to
ameliorate hepatic cirrhosis. The aim of this study was to evaluate the effect of Pirfenidone in …

The aim of this study was to assess the reversibility of cirrhosis after therapy in a large series
of patients with cirrhosis from various etiologies. We performed a retrospective study of 113 …

Three important features must be considered when proposing therapeutic strategies in liver
cirrhosis: inflammation, oxidative stress and fibrogenesis. Pirfenidone is a synthetic …

Hypothesis Simplified evaluation based on clinical and biochemical variables might predict
the degree of hepatic fibrosis in patients with postcholecystectomy bile duct strictures …

Obstructive jaundice, caused by either benign or malignant disease, is associated with a
high rate of postoperative complications and mortality (37, 50). Sepsis, bleeding, renal …

Abstract Plasminogen activator inhibitor‐1 (PAI‐1) is the main inhibitor of plasminogen
activators, thereby playing a major role in fibrinolysis. Whereas hyperfibrinolysis is common …

Plasminogen activator inhibitor-1 (PAI-1) is an acute phase protein that has been shown to
play a role in experimental fibrosis caused by bile duct ligation (BDL) in mice. However, its …