More than half a century after the discovery of the molecular basis of Sickle Cell Disease
(SCD), the causes of the phenotypic heterogeneity of the disease remain unclear. This …

Studies of genetic variants and their associations with disease outcomes using recent
molecular technology advances and the broad variety of statistical methodologies available …

The most important and reliable resource for treating diseases of the liver For more than 55
years," Schiff" has been acclaimed as the most outstanding liver book in the world. This new …

Severe neonatal unconjugated hyperbilirubinemia, with the risk of bilirubin encephalopathy
or kernicterus in severe, untreated cases, occurs when bilirubin production exceeds the …

Bilirubin is a product of heme degradation. Normally, 70‐80% derives from hemoglobin in
senescent erythrocytes. The rest reflects degradation of other hemoproteins. Unconjugated …

Background To determine the prevalence of Xmn1‐Gγ polymorphism in North Indian
children and adolescents with β thalassemia intermedia (TI) and to correlate it with disease …

Present study was aimed to explore the effect of (TA) n UGT1A1 gene promoter
polymorphism on bilirubin metabolism, bilirubinaemia, predisposition to cholelithiasis and …

Hereditary anemias show considerable variation in their clinical presentation. In some
cases, the causes of these variations are easily apparent. In thalassemia (or in …

Aim. To determine the implication of the polymorphism, namely, A (TA) nTAA of UGT1A1 in
lithogenesis for the first time in Tunisia among sickle cell anemia (SCA) children patients …

Background Gilbert syndrome is an inherited disease characterised by mild unconjugated
hyperbilirubinaemia caused by mutations in UGT1A1 gene which lead to decreased activity …