Why nanoparticles prefer liver macrophage cell uptake in vivo

W Ngo, S Ahmed, C Blackadar, B Bussin, Q Ji… - Advanced Drug Delivery …, 2022 - Elsevier
Effective delivery of therapeutic and diagnostic nanoparticles is dependent on their ability to
accumulate in diseased tissues. However, most nanoparticles end up in liver macrophages …

Understanding nanomaterial–liver interactions to facilitate the development of safer nanoapplications

J Li, C Chen, T Xia - Advanced Materials, 2022 - Wiley Online Library
Nanomaterials (NMs) are widely used in commercial and medical products, such as
cosmetics, vaccines, and drug carriers. Exposure to NMs via various routes such as dermal …

Targeting tumor-associated macrophages in hepatocellular carcinoma: biology, strategy, and immunotherapy

H Zheng, X Peng, S Yang, X Li, M Huang, S Wei… - Cell Death …, 2023 - nature.com
Hepatocellular carcinoma (HCC), one of the most malignant tumors, is characterized by its
stubborn immunosuppressive microenvironment. As one of the main members of the tumor …

GABAA Receptor‐Specific Carbon Dots for High‐Contrast Hepatocellular Carcinoma Imaging and Differentiation

Y Guo, Y Sun, X Geng, J Wang, J Hu… - Advanced Functional …, 2024 - Wiley Online Library
Targeted fluorescence probes for imaging and differentiation of hepatocellular carcinoma
(HCC) are highly desirable from its scientific research and clinical applications. However …

Enhancing immunity with nanomedicine: employing nanoparticles to harness the immune system

CT Perciani, LY Liu, L Wood, SA MacParland - ACS nano, 2020 - ACS Publications
The failure of immune responses to vaccines and dysfunctional immune responses to viral
infection, tumor development, or neoantigens lead to chronic viral infection, tumor …

Experimental models of hepatocellular carcinoma—a preclinical perspective

A Blidisel, I Marcovici, D Coricovac, F Hut… - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is characterized by a broad molecular
and genetic heterogeneity, which makes it a challenging subject in terms of the underlying …

Animal models of hepatitis B virus infection–success, challenges, and future directions

Y Liu, S Maya, A Ploss - Viruses, 2021 - mdpi.com
Chronic hepatitis B virus (HBV) infection affects more than 250 million people worldwide,
which greatly increases the risk for terminal liver diseases, such as liver cirrhosis and …

Tumor-associated macrophages-mediated CXCL8 infiltration enhances breast cancer metastasis: Suppression by Danirixin

G Nie, X Cao, Y Mao, Z Lv, M Lv, Y Wang… - International …, 2021 - Elsevier
Breast cancer is the most frequent cancer among females and the second most common
cause of cancer deaths worldwide. Tumor-associated macrophages (TAMs) are the most …

Omics‐Enhanced Nanomedicine for Cancer Therapy

L Qi, Z Li, J Liu, X Chen - Advanced Materials, 2024 - Wiley Online Library
Cancer nanomedicine has emerged as a promising approach to overcome the limitations of
conventional cancer therapies, offering enhanced efficacy and safety in cancer …

High-molecular-weight Fractions of Spruce and Eucalyptus Lignin as a perspective nanoparticle-based Platform for a therapy Delivery in liver cancer

IV Pylypchuk, H Suo… - … in Bioengineering and …, 2022 - frontiersin.org
The natural polymer, lignin, possesses unique biodegradable and biocompatible properties,
making it highly attractive for the generation of nanoparticles for targeted cancer therapy. In …