Aging has a profound and devastating effect on the brain. Old age is accompanied by
declining cognitive function and enhanced risk of brain diseases, including cancer and …

Neural stem cells in the adult mammalian brain are the source of new neurons that
contribute to complex sensory and cognitive functions. Most adult neural stem cells are …

Aging involves a decline in neural function that contributes to cognitive impairment and
disease. However, the mechanisms underlying the transition from a young-and-healthy to …

Neurogenesis persists in adult mammals in specific brain areas, known as neurogenic
niches. Adult neurogenesis is highly dynamic and is modulated by multiple physiological …

All multicellular organisms undergo a decline in tissue and organ function as they age. An
attractive theory is that a loss in stem cell number and/or activity over time causes this …

Ageing impairs the ability of neural stem cells (NSCs) to transition from quiescence to
proliferation in the adult mammalian brain. Functional decline of NSCs results in the …

Neural stem cells (NSCs) reside in specialized niches in the adult mammalian brain. The
ventricular–subventricular zone (V‐SVZ), adjacent to the lateral ventricles, gives rise to …

Recent advances in our understanding of tissue regeneration and the development of
efficient approaches to induce and differentiate pluripotent stem cells for cell replacement …

Endothelial cells (ECs) form an extensive network of blood vessels that has numerous
essential functions in the vertebrate body. In addition to their well-established role as a …

Aging is the main risk factor for Alzheimer's disease (AD); being associated with
conspicuous changes on microglia activation. Aged microglia exhibit an increased …