Retrospect, advances and challenges in Chagas disease diagnosis: A comprehensive review

AG Schijman, J Alonso-Padilla, C Britto… - The Lancet Regional …, 2024 - thelancet.com
Chagas disease, caused by Trypanosoma cruzi, affects millions worldwide. The 2030 WHO
roadmap aims to eliminate it as a public health concern, emphasising the need for timely …

Practical diagnostic algorithms for Chagas disease: a focus on low resource settings

JC Gabaldón-Figueira, M Skjefte, S Longhi… - Expert Review of Anti …, 2023 - Taylor & Francis
Introduction Chagas disease, caused by parasite Trypanosoma cruzi, is the most important
neglected tropical disease in the Americas. Two drugs are available for treatment, but …

Chronic intestinal pseudo‐obstruction in adults: a practical guide to identify patient subgroups that are suitable for more specific treatments

G Basilisco, M Marchi, M Coletta - Neurogastroenterology & …, 2024 - Wiley Online Library
Chronic intestinal pseudo‐obstruction is a rare and heterogeneous syndrome characterized
by recurrent symptoms of intestinal obstruction with radiological features of dilated small or …

Formulation of benznidazole-lipid nanocapsules: Drug release, permeability, biocompatibility, and stability studies

EC Arrua, O Hartwig, B Loretz, X Murgia, DK Ho… - International Journal of …, 2023 - Elsevier
Benznidazole, a poorly soluble in water drug, is the first-line medication for the treatment of
Chagas disease, but long treatment periods at high dosages cause several adverse effects …

Accuracy of diagnostic tests for the detection of Chagas disease: A systematic review and meta-analysis

MA Candia-Puma, LY Machaca-Luque… - Diagnostics, 2022 - mdpi.com
The present systematic review and meta-analysis about the accuracy of diagnostic tests aim
to describe the findings of literature over the last thirty years for the diagnosis of Chagas …

Elucidating the complexation of nifurtimox with cyclodextrins

G Bedogni, E Arrúa, K Seremeta, N Okulik… - Journal of Molecular …, 2023 - Elsevier
Abstract Chagas disease or American Trypanosomiasis, caused by the parasite
Trypanosoma cruzi, is an endemic neglected infection found in 21 countries across Latin …

[HTML][HTML] Exercise-based training programs for patients with chronic Chagas cardiomyopathy: A systematic review and meta-analysis

PM Calderon-Ramirez, D Fernandez-Guzman… - IJC Heart & …, 2023 - Elsevier
Background We assessed the effects of exercise-based training programs (EBTP) in patients
with chronic Chagas cardiomyopathy (CCC) through a systematic review and meta-analysis …

Polyamine Metabolism for Drug Intervention in Trypanosomatids

Y Pérez-Pertejo, C García-Estrada… - Pathogens, 2024 - mdpi.com
Neglected tropical diseases transmitted by trypanosomatids include three major human
scourges that globally affect the world's poorest people: African trypanosomiasis or sleeping …

Oral Chagas disease outbreak by bacaba juice ingestion: A century after Carlos Chagas' discovery, the disease is still hard to manage

EA Simões-Neto, DWCL Santos… - PLOS Neglected …, 2024 - journals.plos.org
Background Orally transmitted acute Chagas disease (ACD) primarily affects low-visibility
and low-income individuals in tropical and subtropical zones. Managing ACD remains …

Unraveling the role of miRNAs as biomarkers in Chagas cardiomyopathy: Insights into molecular pathophysiology

HG Ribeiro, OA Galdino, KSC de Souza… - PLOS Neglected …, 2024 - journals.plos.org
Background Chagas cardiomyopathy (ChCM) is a severe form of Chagas disease and a
major cause of cardiovascular morbidity and mortality. The dysregulation of the immune …