Terpenoids with lactone moieties have been indicated to possess high bioactivity. Certain
terpenoid lactones exist in nature, in plants and animals, but they can also be obtained by …

Cuminaldehyde (CUM) is a bioactive compound majorly present in the seeds of Cuminum
cyminum. The plant C. cyminum is the hub of numerous bioactive compounds that have …

The design of hybrid (chimeric) molecules containing two different pharmacophores
connected via a spacer (linker) is a promising approach to the functionalization of natural …

Four stereoisomers of δ-iodo-γ-lactones with p-isopropylphenyl substituent at β-position: cis-
(4R, 5R, 6S)-1, cis-(4S, 5S, 6R)-2, trans-(4R, 5S, 6R)-3, trans-(4S, 5R, 6S)-4 with proved …

Three novel enantiomeric pairs of bromolactones possesing a 2, 5-dimethylphenyl
substituent at the β-position of the lactone ring have been synthesized from corresponding …

For many years, studies focused on developing new natural or synthetic compounds with
antineoplastic activity have attracted the attention of researchers. An interesting group of …

The possibility of using Lecitase® Ultra as a novel alternative biocatalyst for the kinetic
resolution of model racemic allyl esters of (E)-4-phenylbut-3-en-3-ol: Acetate (4a) and …

Starting from 1-acetyl-1-cyclohexene, three enantiomeric pairs (ee≥ 99%) of bicyclic δ-halo-
γ-lactones with cyclohexane ring were obtained in five-step synthesis. The key …

The influence of buffer type, co-solvent type, and acyl chain length was investigated for the
enantioselective hydrolysis of racemic 4-arylbut-3-en-2-yl esters using Lecitase™ Ultra (LU) …

Searching for the new anticancer compounds we prepared three new β-cyclocitral-derived
hydroxyl-γ-lactones by microbial hydroxylation of tetramethyl-substituted bicyclic γ-lactone …