Diversity, structure and regulation of microbial metallothionein: metal resistance and possible applications in sequestration of toxic metals

S Chatterjee, S Kumari, S Rath, M Priyadarshanee… - Metallomics, 2020 - academic.oup.com
Metallothioneins (MTs) are a group of cysteine-rich, universal, low molecular weight proteins
distributed widely in almost all major taxonomic groups ranging from tiny microbes to highly …

Toxicity of ZnO and CuO nanoparticles to ciliated protozoa Tetrahymena thermophila

M Mortimer, K Kasemets, A Kahru - Toxicology, 2010 - Elsevier
The toxic effects of nanoparticles (NPs) of ZnO and CuO to particle-ingesting model
organism protozoa Tetrahymena thermophila were evaluated. Nano-ZnO was remarkably …

Ciliate metallothioneins: unique microbial eukaryotic heavy-metal-binder molecules

JC Gutiérrez, F Amaro, S Diaz, P De Francisco… - JBIC Journal of …, 2011 - Springer
This article represents an updated review of ciliate metallothioneins (Tetrahymena species)
including a comparative analysis with regard to well-known metallothioneins (MTs) from …

Whole‐cell biosensors for detection of heavy metal ions in environmental samples based on metallothionein promoters from Tetrahymena thermophila

F Amaro, AP Turkewitz… - Microbial …, 2011 - Wiley Online Library
Heavy metals are among the most serious pollutants, and thus there is a need to develop
sensitive and rapid biomonitoring methods for heavy metals in the environment. Critical …

The Tetrahymena metallothionein gene family: twenty-one new cDNAs, molecular characterization, phylogenetic study and comparative analysis of the gene …

P de Francisco, LM Melgar, S Díaz, A Martín-González… - BMC genomics, 2016 - Springer
Abstract Background Ciliate metallothioneins (MTs) are included in family 7 of the MT
superfamily. This family has been divided into two main subfamilies: 7a or CdMTs and 7b or …

From heavy metal‐binders to biosensors: Ciliate metallothioneins discussed

JC Gutierrez, F Amaro, A Martín‐González - BioEssays, 2009 - Wiley Online Library
Metallothioneins (MTs) are ubiquitous proteins with the capacity to bind heavy metal ions
(mainly Cd, Zn or Cu), and they have been found in animals, plants, eukaryotic and …

[HTML][HTML] Hints for metal-preference protein sequence determinants: different metal binding features of the five Tetrahymena thermophila metallothioneins

A Espart, M Marín, S Gil-Moreno… - … journal of biological …, 2015 - ncbi.nlm.nih.gov
The metal binding preference of metallothioneins (MTs) groups them in two extreme
subsets, the Zn/Cd-and the Cu-thioneins. Ciliates harbor the largest MT gene/protein family …

Cellular and molecular basis of heavy metal-induced stress in ciliates

S Somasundaram, JS Abraham, S Maurya, S Makhija… - Current science, 2018 - JSTOR
Globally, heavy metals are the major pollutants present in both terrestrial and aquatic
ecosystems. Increase in their concentration due to various anthropogenic activities is a …

Extreme metal adapted, knockout and knockdown strains reveal a coordinated gene expression among different Tetrahymena thermophila metallothionein isoforms

P De Francisco, A Martin-Gonzalez, AP Turkewitz… - PLoS …, 2017 - journals.plos.org
Metallothioneins (MT) constitute a superfamily of small cytosolic proteins that are able to
bind metal cations through numerous cysteine (Cys) residues. Like other organisms the …

Tetrahymena Glutathione Peroxidase Family: A Comparative Analysis of These Antioxidant Enzymes and Differential Gene Expression to Metals and Oxidizing …

LL Cubas-Gaona, P de Francisco, A Martín-González… - Microorganisms, 2020 - mdpi.com
In the present work, an extensive analysis of the putative glutathione peroxidases (GPx) of
the eukaryotic microorganism model Tetrahymena thermophila is carried out. A comparative …