Growth of new blood vessels is considered requisite to cancer progression. Recent findings
revealed that in addition to inducing angiogenesis, tumor-derived factors alter endothelial …

Precision oncology relies on detailed molecular analysis of how diverse tumours respond to
various therapies, with the aim to optimize treatment outcomes for individual patients. Patient …

The vascular endothelium supplies nutrients and oxygen to different body organs and
supports the progression of diseases such as cancer through angiogenesis. Pathological …

Antibody-drug conjugates (ADC) represent one of the most successful therapeutic
approaches introduced into clinical practice in the last few years. Loncastuximab tesirine …

T cell-based immunotherapies have demonstrated effectiveness in treating diffuse large B
cell lymphoma (DLBCL) and follicular lymphoma (FL) but predicting response and …

Leukemias are refractory hematological malignancies, characterized by marked intrinsic
heterogeneity which poses significant obstacles to effective treatment. However, traditional …

Classic Hodgkin lymphoma (cHL) is characterized by a rich immune microenvironment as
the main tumor component. It involves a broad range of cell populations, which are largely …

Simple Summary Leukemic cells evade chemotherapy due to interactions within the bone
marrow microenvironment. We have tested the effect of epigenetic therapy on pediatric AML …

Extensive research over the past 50 years has resulted in significant improvements in
survival for patients diagnosed with leukemia. Despite this, a subgroup of patients harboring …

Acute lymphoblastic leukemia (ALL) preferentially localizes in the bone marrow (BM) and
displays recurrent patterns of medullary and extra-medullary involvement. Leukemic cells …