Mechanisms of protein homeostasis are crucial for overseeing the clearance of misfolded
and toxic proteins over the lifetime of an organism, thereby ensuring the health of neurons …

The physiological balance between excitation and inhibition in the brain is significantly
affected in Alzheimer's disease (AD). Several neuroactive compounds and their signaling …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
aggregation of ubiquitinated proteins in affected motor neurons. Recent studies have …

Transactive response DNA-binding protein 43 kD (TDP-43) is an aggregation-prone prion-
like domain-containing protein and component of pathological intracellular aggregates …

RNA-binding proteins, and in particular TAR DNA-binding protein 43 (TDP43), are central to
the pathogenesis of motor neuron diseases and related neurodegenerative disorders …

Transactivating response region DNA binding protein (TDP-43) is the major protein
component of ubiquitinated inclusions found in amyotrophic lateral sclerosis (ALS) and …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease affecting upper and
lower motor neurons in the central nervous system. Patients with ALS develop extensive …

TAR DNA‐binding protein (TDP‐43) is an evolutionarily conserved heterogeneous nuclear
ribonucleoprotein (hnRNP) involved in RNA processing, whose abnormal cellular …

Loss of the nuclear RNA binding protein TAR DNA binding protein-43 (TDP-43) into
cytoplasmic aggregates is the strongest correlate to neurodegeneration in amyotrophic …

Accumulation of phosphorylated cytoplasmic TDP-43 inclusions accompanied by loss of
normal nuclear TDP-43 in neurons and glia of the brain and spinal cord are the molecular …