Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system and
common cause of non-traumatic neurological disability in young adults. The likelihood for an …

Genome-wide association studies (GWASs) have become the focus of the statistical analysis
of complex traits in humans, successfully shedding light on several aspects of genetic …

Association studies have greatly refined the understanding of how variation within the
human leukocyte antigen (HLA) genes influences risk of multiple sclerosis. However, the …

The uneven distribution of multiple sclerosis (MS) across populations can be attributed to
differences in genes and the environment and their interaction. Prevalence and incidence …

(WTCCC2) consortia is provided in the Supplementary Note online. Author Contributions
FC, ADB, CEMG, J. Kere., A. Reis, JNB and RCT oversaw cohort collection for both the …

BACKGROUND: Genome-wide association studies (GWAS) for Parkinson's disease have
linked two loci (MAPT and SNCA) to risk of Parkinson's disease. We aimed to identify novel …

Multiple sclerosis (MS) is a common, complex neurological disease. The precise aetiology of
MS is not yet known, although epidemiological data indicate that both genetic and …

Background Idiopathic membranous nephropathy is a major cause of the nephrotic
syndrome in adults, but its etiologic basis is not fully understood. We investigated the genetic …

Genome-wide association studies have revolutionised the genetic analysis of multiple
sclerosis. Through international collaborative efforts involving tens of thousands of cases …

Although strong genetic determinants of multiple sclerosis (MS) exist, the findings of
migration studies support a role for environmental factors in this disease. Through rigorous …