Quorum sensing going wild

M Spacapan, C Bez, V Venturi - Iscience, 2023 - cell.com
The first discovered and well-characterized bacterial quorum sensing (QS) system belongs
to Vibrio fischeri, which uses N-acyl homo-serine lactones (AHLs) for cell-cell signaling. AHL …

Inhibition of PQS signaling by the Pf bacteriophage protein PfsE enhances viral replication in Pseudomonas aeruginosa

CM Schwartzkopf, VL Taylor, MC Groleau… - Molecular …, 2024 - Wiley Online Library
Quorum sensing, a bacterial signaling system that coordinates group behaviors as a
function of cell density, plays an important role in regulating viral (phage) defense …

Genetic and transcriptomic characteristics of RhlR-dependent quorum sensing in cystic fibrosis isolates of Pseudomonas aeruginosa

KL Asfahl, NE Smalley, AP Chang, AA Dandekar - Msystems, 2022 - Am Soc Microbiol
In people with the genetic disease cystic fibrosis (CF), bacterial infections involving the
opportunistic pathogen Pseudomonas aeruginosa are a significant cause of morbidity and …

Relationship of the transcription factor MexT to quorum sensing and virulence in Pseudomonas aeruginosa

M Kostylev, NE Smalley, MH Chao… - Journal of …, 2023 - Am Soc Microbiol
Quorum sensing (QS) regulates expression of many virulence genes in the opportunistic
human pathogen Pseudomonas aeruginosa. There are two acyl-homoserine lactone (AHL) …

The relationship between pqs gene expression and acylhomoserine lactone signaling in Pseudomonas aeruginosa

MP Soto-Aceves, NE Smalley, AL Schaefer… - Journal of …, 2024 - journals.asm.org
The opportunistic pathogen Pseudomonas aeruginosa has complex quorum sensing (QS)
circuitry, which involves two acylhomoserine lactone (AHL) systems, the LasI AHL synthase …

A balancing act: investigations on the impact of altered signal sensitivity in bacterial quorum sensing

SW Miranda, EP Greenberg - Journal of Bacteriology, 2023 - Am Soc Microbiol
Many bacterial species communicate and cooperate with kin using a form of cell-cell
signaling called quorum sensing. Sensitivity and selectivity are fundamental properties of …

Evolution of Quorum Sensing in Pseudomonas aeruginosa Can Occur via Loss of Function and Regulon Modulation

P Jayakumar, ART Figueiredo, R Kümmerli - Msystems, 2022 - Am Soc Microbiol
Pseudomonas aeruginosa populations evolving in cystic fibrosis lungs, animal hosts, natural
environments and in vitro undergo extensive genetic adaption and diversification. A …

Signatures of kin selection in a natural population of the bacteria Bacillus subtilis

LJ Belcher, AE Dewar, C Hao, M Ghoul… - Evolution …, 2023 - academic.oup.com
Laboratory experiments have suggested that bacteria perform a range of cooperative
behaviors, which are favored because they are directed toward relatives (kin selection) …

Frequency of quorum-sensing mutations in Pseudomonas aeruginosa strains isolated from different environments

K O'Connor, CY Zhao, M Mei, SP Diggle - Microbiology, 2022 - microbiologyresearch.org
Pseudomonas aeruginosa uses quorum sensing (QS) to coordinate the expression of
multiple genes necessary for establishing and maintaining infection. It has previously been …

Tripartite interactions between filamentous Pf4 bacteriophage, Pseudomonas aeruginosa, and bacterivorous nematodes

CM Schwartzkopf, AJ Robinson, M Ellenbecker… - PLoS …, 2023 - journals.plos.org
The opportunistic pathogen Pseudomonas aeruginosa PAO1 is infected by the filamentous
bacteriophage Pf4. Pf4 virions promote biofilm formation, protect bacteria from antibiotics …