The extracellular matrix (ECM) is an essential component of the heart that imparts
fundamental cellular processes during organ development and homeostasis. Most …

The hallmark of most cardiac diseases is the progressive loss of cardiomyocytes. In the
perinatal period, cardiomyocytes still proliferate, and the heart shows the capacity to …

Human heart failure, a leading cause of death worldwide, is a prominent example of a
chronic disease that may result from poor cell renewal. The Hippo signaling pathway is an …

Background: The adult mammalian heart has limited regenerative capacity, mostly
attributable to postnatal cardiomyocyte cell cycle arrest. In the last 2 decades, numerous …

We have previously developed a high-throughput bioengineered human cardiac organoid
(hCO) platform, which provides functional contractile tissue with biological properties similar …

The adult mammalian heart has limited capacity for regeneration following injury, whereas
the neonatal heart can readily regenerate within a short period after birth. Neonatal heart …

The neonatal mammalian heart is capable of regeneration for a brief window of time after
birth. However, this regenerative capacity is lost within the first week of life, which coincides …

Background: A key cause of the high mortality of cardiovascular diseases is the
cardiomyocyte inability to renew after cardiac injury. As a promising strategy to supplement …

Cardiomyocyte loss after injury results in adverse remodelling and fibrosis, inevitably
leading to heart failure. The ERBB2–Neuregulin and Hippo–YAP signalling pathways are …

Cell therapy treatment of myocardial infarction (MI) is mediated, in part, by exosomes
secreted from transplanted cells. Thus, we compared the efficacy of treatment with a mixture …