Superoxide is a primary oxygen radical that is produced when an oxygen molecule receives
one electron. Superoxide dismutase (SOD) plays a primary role in the cellular defense …

The number of old people is rising worldwide, and advancing age is a major risk factor for
atherosclerotic cardiovascular disease. However, the mechanisms underlying this …

Among other mechanisms, oxidative stress has been postulated to play an important role in
the rate of ageing. Oxidative damage contributes to the hallmarks of ageing and essential …

Superoxide dismutases (SODs) are universal enzymes of organisms that live in the
presence of oxygen. They catalyze the conversion of superoxide into oxygen and hydrogen …

Oxidative stress in skin plays a major role in the aging process. This is true for intrinsic aging
and even more for extrinsic aging. Although the results are quite different in dermis and …

Age is the most important risk factor for most diseases. Mitochondria play a central role in
bioenergetics and metabolism. In addition, several lines of evidence indicate the impact of …

Although historically viewed as purely harmful, recent evidence suggests that reactive
oxygen species (ROS) function as important physiological regulators of intracellular …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from
aerobic metabolism, as a result of accidental electron leakage as well as regulated …

Oxidative stress, defined as an excess production of reactive oxygen species (ROS) relative
to antioxidant defense, has been shown to play an important role in the pathophysiology of …

Sexual dimorphism is a key factor to consider in the ageing process given the impact that it
has on life expectancy. The oxidative-inflammatory theory of ageing states that the ageing …