Liquid chromatography-mass spectrometry analysis of small molecules from biofluids
requires sensitive and robust assays. Because of the very complex nature of many biological …

The treatment of many malignancies has been improved in recent years by the introduction
of molecular targeted therapies. These drugs interact preferentially with specific targets that …

A new liquid chromatography–tandem mass spectrometry (LC–MS/MS) method, performed
by electrospray ionization in positive mode using a triple quadrupole mass spectrometry …

This paper presents the permeability analysis of neuroactive drugs and correlation with in
vivo brain/plasma ratios in a dynamic microfluidic blood–brain barrier (BBB) model …

To support pharmacokinetic‐guided dosing in individual patients, a fast and accurate
method for simultaneous determination of anticancer tyrosine kinase inhibitors (TKIs) …

Gas-phase N-doped graphene (gNG) was synthesized by a modified thermal annealing
method using gaseous melamine as nitrogen source and then for the first time applied as a …

The therapeutic activity of drugs can be optimized by establishing an individualized dosage,
based on the measurement of the drug concentration in the serum, particularly if the drugs …

Background: A sensitive liquid chromatography coupled with tandem mass spectrometry
(MS/MS) method for the analysis in a small volume of plasma of 14 tyrosine kinase inhibitors …

A sensitive, sophisticated and practical bioanalytical assay for the simultaneous
determination of six tyrosine kinase inhibitors (imatinib, sunitinib, nilotinib, dasatinib …

Dasatinib is an oral second-generation tyrosine kinase inhibitor known to be used widely in
Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) and Ph+ acute …