Dysbiosis is associated with various diseases. The composition and diversity of gut
microbiota affect host physiology through the production of bioactive metabolites. Short …

Alzheimer's disease (AD) is a progressive neurodegenerative disease and is closely
associated with the accumulation of β-amyloid (Aβ) and neurofibrillary tangles (NFTs). Apart …

Genetic association studies have demonstrated the critical involvement of the microglial
immune response in Alzheimer's disease (AD) pathogenesis. Phospholipase C-gamma-2 …

Summary Hydroxycarboxylic acid receptor 2 (HCAR2), modulated by endogenous ketone
body β-hydroxybutyrate and exogenous niacin, is a promising therapeutic target for …

Background Alzheimer's disease (AD) is associated with metabolic abnormalities linked to
critical elements of neurodegeneration. We recently administered combined metabolic …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
accumulation of Aβ plaques and neurofibrillary tangles, resulting in synaptic loss and …

The hydroxycarboxylic acid receptor 2 (HCA2) agonist niacin has been used as treatment for
dyslipidemia for several decades albeit with skin flushing as a common side-effect in treated …

Alzheimer's disease (AD) is the most common type of dementia that affects millions of
individuals worldwide. It is an irreversible neurodegenerative disorder that is characterized …

Nowadays, nutraceuticals are being incorporated into functional foods or used as
supplements with nonpharmacological approaches in the prevention and management of …

Niacin (vitamin B3) is an essential nutrient that treats pellagra, and prior to the advent of
statins, niacin was commonly used to counter dyslipidemia. Recent evidence has posited …