Breast cancer heterogeneity determines cancer progression, treatment effects, and
prognosis. However, the precise mechanism for this heterogeneity remains unknown owing …

The tumor microenvironment (TME) is made up of cells and extracellular matrix (non-cellular
component), and cellular components include cancer cells and non-malignant cells such as …

Obesity, exceptionally prevalent in the USA, promotes the incidence and progression of
numerous cancer types including breast cancer. Complex, interacting metabolic and …

The extracellular matrix (ECM) is an important component of the tumor microenvironment
(TME), having several important roles related to the hallmarks of cancer. In cancer, multiple …

Breast cancer is one of the leading causes of mortality in females. Over the past decades,
intensive efforts have been made to uncover the pathogenesis of breast cancer. Interleukin …

Breast cancer (BC) is a malignant breast tumor confronted with high invasion, metastasis
and recurrence rate, and adipocytes are the largest components in breast tissue. The …

Adipocytes influence breast cancer behaviour via fatty acid release into the tumour
microenvironment. Co-culturing human adipocytes and breast cancer cells increased CD36 …

The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3)
is activated constitutively in a wide array of human cancers. It is an appealing molecular …

Currently, metastasis remains the primary cause of death of patients with breast cancer
despite the important advances in the treatment of this disease. In the complex tumour …

Metabolic syndrome is a type of multifactorial metabolic disease with the presence of at least
three factors: obesity, diabetes mellitus, low high-density lipoprotein, hypertriglyceridemia …