Update on pathomechanisms and treatments in allergic rhinitis
Y Zhang, F Lan, L Zhang - Allergy, 2022 - Wiley Online Library
Allergic rhinitis (AR) is a global health problem with increasing prevalence and association
with an enormous medical and socioeconomic burden. New recognition of immune cells …
with an enormous medical and socioeconomic burden. New recognition of immune cells …
The role of transcription factors in shaping regulatory T cell identity
Forkhead box protein 3-expressing (FOXP3+) regulatory T cells (Treg cells) suppress
conventional T cells and are essential for immunological tolerance. FOXP3, the master …
conventional T cells and are essential for immunological tolerance. FOXP3, the master …
CD4+ T cells exhibit distinct transcriptional phenotypes in the lymph nodes and blood following mRNA vaccination in humans
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mRNA
vaccination induce robust CD4+ T cell responses. Using single-cell transcriptomics, here …
vaccination induce robust CD4+ T cell responses. Using single-cell transcriptomics, here …
Influenza vaccination stimulates maturation of the human T follicular helper cell response
The differentiation and specificity of human CD4+ T follicular helper cells (TFH cells) after
influenza vaccination have been poorly defined. Here we profiled blood and draining lymph …
influenza vaccination have been poorly defined. Here we profiled blood and draining lymph …
IL-12 drives the differentiation of human T follicular regulatory cells
D Castaño, S Wang, S Atencio-Garcia, EJ Shields… - Science …, 2024 - science.org
T follicular regulatory (Tfr) cells can counteract the B cell helper activity of T follicular helper
(Tfh) cells and hinder the production of antibodies against self-antigens or allergens. A …
(Tfh) cells and hinder the production of antibodies against self-antigens or allergens. A …
T follicular cells: The regulators of germinal center homeostasis
The formation of high-affinity antibodies that protect against infection requires the formation
of germinal centres (GCs), where specialized T follicular helper cells (Tfh) provide help to B …
of germinal centres (GCs), where specialized T follicular helper cells (Tfh) provide help to B …
Reduced follicular regulatory T cells in spleen and pancreatic lymph nodes of patients with type 1 diabetes
A Vecchione, T Jofra, J Gerosa, K Shankwitz… - Diabetes, 2021 - Am Diabetes Assoc
In the attempt to understand the origin of autoantibody (AAb) production in patients with and
at risk for type 1 diabetes (T1D), multiple studies have analyzed and reported alterations in T …
at risk for type 1 diabetes (T1D), multiple studies have analyzed and reported alterations in T …
T follicular helper cells and T peripheral helper cells in rheumatic and musculoskeletal diseases
M Akiyama, W Alshehri, K Yoshimoto… - Annals of the rheumatic …, 2023 - ard.bmj.com
Recent technological progress has greatly advanced our understanding of human
immunology. In particular, the discovery of human T follicular helper (Tfh) and T peripheral …
immunology. In particular, the discovery of human T follicular helper (Tfh) and T peripheral …
Different antibody-associated autoimmune diseases have distinct patterns of T follicular cell dysregulation
Autoantibodies are produced within germinal centers (GC), in a process regulated by
interactions between B, T follicular helper (Tfh), and T follicular regulatory (Tfr) cells. The GC …
interactions between B, T follicular helper (Tfh), and T follicular regulatory (Tfr) cells. The GC …
A review of CD4+ T cell differentiation and diversity in dogs
HP Lang, KC Osum, SG Friedenberg - Veterinary immunology and …, 2024 - Elsevier
CD4+ T cells are an integral component of the adaptive immune response, carrying out
many functions to combat a diverse range of pathogenic challenges. These cells exhibit …
many functions to combat a diverse range of pathogenic challenges. These cells exhibit …